ArticleJournal of immunology (Baltimore, Md. : 1950)2015
Cutting edge: Bcl6-interacting corepressor contributes to germinal center T follicular helper cell formation and B cell helper function.
Article in Journal of immunology (Baltimore, Md. : 1950), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 30 citations in OpenAlex.
- Pathogenic roles of follicular helper T cells in IgG4-related disease and implications for potential therapy.Frontiers in immunology · 2024Review
- The regulation of Tfh cell differentiation by β-hydroxybutyrylation modification of transcription factor Bcl6.Chromosoma · 2023Article
- The Chromatin Regulator Mll1 Supports T Follicular Helper Cell Differentiation by Controlling Expression of Bcl6, LEF-1, and TCF-1.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Targeting Bcl6 in the TREX1 D18N murine model ameliorates autoimmunity by modulating T-follicular helper cells and germinal center B cells.European journal of immunology · 2022Article
- The Pathologic and Genetic Characteristics of Extranodal NK/T-Cell Lymphoma.Life (Basel, Switzerland) · 2022Review
- BCOR gene alterations in hematologic diseases.Blood · 2021Review
- Transcription tipping points for T follicular helper cell and T-helper 1 cell fate commitment.Cellular & molecular immunology · 2021Review
- OFCD syndrome and extraembryonic defects are revealed by conditional mutation of the Polycomb-group repressive complex 1.1 (PRC1.1) gene BCOR.Developmental biology · 2020Article
- Mechanism of Follicular Helper T Cell Differentiation Regulated by Transcription Factors.Journal of immunology research · 2020Review
- BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors.The Journal of experimental medicine · 2019Article
- Maternal Immunity Influences Vertical Transmission of Hepatitis B to Newborns.Hepatology communications · 2019Article
- Cutting Edge: T Cell-Dependent Plasmablasts Form in the Absence of Single Differentiated CD4Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Alum adjuvant is more effective than MF59 at prompting early germinal center formation in response to peptide-protein conjugates and enhancing efficacy of a vaccine against opioid use disorders.Human vaccines & immunotherapeutics · 2019Article
- Polymicrobial Sepsis Chronic Immunoparalysis Is Defined by Diminished Ag-Specific T Cell-Dependent B Cell Responses.Frontiers in immunology · 2018Article
- BCL6 represses antiviral resistance in follicular T helper cells.Journal of leukocyte biology · 2017Article
- Cutting Edge: Adenosine A2a Receptor Signals Inhibit Germinal Center T Follicular Helper Cell Differentiation during the Primary Response to Vaccination.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Novel High-grade Endometrial Stromal Sarcoma: A Morphologic Mimicker of Myxoid Leiomyosarcoma.The American journal of surgical pathology · 2017Article
- Belatacept Does Not Inhibit Follicular T Cell-Dependent B-Cell Differentiation in Kidney Transplantation.Frontiers in immunology · 2017Article
- Regulation of hematopoietic development by ZBTB transcription factors.International journal of hematology · 2016Review
- Regulators of Tfh Cell Differentiation.Frontiers in immunology · 2016Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
CD4(+) germinal center (GC)-T follicular helper (Tfh) cells help B cells become long-lived plasma cells and memory cells. The transcriptional repressor Bcl6 plays a key role in GC-Tfh formation by inhibiting the expression of genes that promote differentiation into other lineages. We determined whether BCOR, a component of a Polycomb repressive complex that interacts with the Bcl6 BTB domain, influences GC-Tfh differentiation. T cell-targeted BCOR deficiency led to a substantial loss of peptide:MHC class II-specific GC-Tfh cells following Listeria monocytogenes infection and a 2-fold decrease following immunization with a peptide in CFA. The reduction in GC-Tfh cells was associated with diminished plasma cell and GC B cell formation. Thus, T cell-expressed BCOR is critical for optimal GC-Tfh cell differentiation and humoral immunity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.