ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2015
Can immunological principles and cross-disciplinary science illuminate the path to vaccines for HIV and other global health challenges?
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Modulating the durability of anti-HIV gp120 antibody responses after vaccination: a comment on Wilson & Karp (2015).Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- A reply to DeVico, Lewis & Gallo (2015).Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Biological challenges to effective vaccines in the developing world.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Vaccines are one of the most impactful and cost-effective public health measures of the twentieth century. However, there remain great unmet needs to develop vaccines for globally burdensome infectious diseases and to allow more timely responses to emerging infectious disease threats. Recent advances in the understanding of immunological principles operative not just in model systems but in humans in concert with the development and application of powerful new tools for profiling human immune responses, in our understanding of pathogen variation and evolution, and in the elucidation of the structural aspects of antibody-pathogen interactions, have illuminated pathways by which these unmet needs might be addressed. Using these advances as foundation, we herein present a conceptual framework by which the discovery, development and iterative improvement of effective vaccines for HIV, malaria and other globally important infectious diseases might be accelerated.
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