ArticleDiabetes2015
A Human Thrifty Phenotype Associated With Less Weight Loss During Caloric Restriction.
Article in Diabetes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07155564 (Energy Balance Within a Whole-Room Indirect Calorimeter and Its Relevance for Energy Expenditure Measures), which is not on this map. Cited by 57 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Energy Balance Within a Whole-Room Indirect Calorimeter and Its Relevance for Energy Expenditure Measures
Who cites it
57 citing papers in PubMed, 89 citations in OpenAlex.
- The Effects of Metabolism Tracker Device (Lumen) Usage on Metabolic Control in Adults with Prediabetes: Pilot Clinical Trial.Obesity facts · 2023Trial
- Reduced adaptive thermogenesis during acute protein-imbalanced overfeeding is a metabolic hallmark of the human thrifty phenotype.The American journal of clinical nutrition · 2021Trial
- Impaired Metabolic Flexibility to High-Fat Overfeeding Predicts Future Weight Gain in Healthy Adults.Diabetes · 2020Trial
- Whole-Room Indirect Calorimetry in the Study of Obesity, Insulin Resistance and Metabolic Flexibility: A Narrative Review.Nutrients · 2026Review
- Specific metabolic rate and body weight regulation: racial and ethnic differences in mass-independent energy expenditure.Journal of endocrinological investigation · 2026Article
- Multilevel metabolic adaptation to exercise training.Communications medicine · 2026Article
- Body weight regulation models in humans: insights for testing their validity.Nature reviews. Endocrinology · 2025Review
- FGF21 as a mediator of adaptive changes in food intake and macronutrient preference in response to protein restriction.Neuropharmacology · 2024Review
- What could be the reasons for not losing weight even after following a weight loss program?Journal of health, population, and nutrition · 2024Review
- Testing a proposed mathematical model of weight loss in women enrolled on a commercial weight-loss programme: the LighterLife study.Journal of nutritional science · 2024Article
- Prenatal caloric restriction adjusts the energy homeostasis and behavior in response to acute and chronic variations in food availability in adulthood.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2023Article
- Obesity: A Review of Pathophysiology and Classification.Mayo Clinic proceedings · 2023Review
- Obesity-induced and weight-loss-induced physiological factors affecting weight regain.Nature reviews. Endocrinology · 2023Review
- Greater anhedonia scores in healthy individuals are associated with less decline in 24-hour energy expenditure with fasting: Evidence for a link between behavioral traits and spendthrift phenotype.Physiology & behavior · 2023Article
- The Influence of Energy Balance and Availability on Resting Metabolic Rate: Implications for Assessment and Future Research Directions.Sports medicine (Auckland, N.Z.) · 2023Review
- The Application of Spearman Partial Correlation for Screening Predictors of Weight Loss in a Multiomics Dataset.Omics : a journal of integrative biology · 2022Article
- Exercise training enhances muscle mitochondrial metabolism in diet-resistant obesity.EBioMedicine · 2022Article
- Effects of Short-term Fasting on Ghrelin/GH/IGF-1 Axis in Healthy Humans: The Role of Ghrelin in the Thrifty Phenotype.The Journal of clinical endocrinology and metabolism · 2022Article
- Targeting skeletal muscle mitochondrial health in obesity.Clinical science (London, England : 1979) · 2022Review
- Metabolic profile in women differs between high versus low energy spenders during a low intensity exercise on a cycle-desk.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Successful weight loss is variable for reasons not fully elucidated. Whether effective weight loss results from smaller reductions in energy expenditure during caloric restriction is not known. We analyzed whether obese individuals with a "thrifty" phenotype, that is, greater reductions in 24-h energy expenditure during fasting and smaller increases with overfeeding, lose less weight during caloric restriction than those with a "spendthrift" phenotype. During a weight-maintaining period, 24-h energy expenditure responses to fasting and 200% overfeeding were measured in a whole-room indirect calorimeter. Volunteers then underwent 6 weeks of 50% caloric restriction. We calculated the daily energy deficit (kilocalories per day) during caloric restriction, incorporating energy intake and waste, energy expenditure, and daily activity. We found that a smaller reduction in 24-h energy expenditure during fasting and a larger response to overfeeding predicted more weight loss over 6 weeks, even after accounting for age, sex, race, and baseline weight, as well as a greater rate of energy deficit accumulation. The success of dietary weight loss efforts is influenced by the energy expenditure response to caloric restriction. Greater decreases in energy expenditure during caloric restriction predict less weight loss, indicating the presence of thrifty and spendthrift phenotypes in obese humans.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.