Evidence map›Paper›PMID 25964272›Full record

ArticleThe Journal of investigative dermatology2015

What is a pragmatic clinical trial?

Hywel C Williams, Esther Burden-Teh, Andrew J Nunn

Abstract read
PubMed Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Interventions for bullous pemphigoid.The Cochrane database of systematic reviews · 2023
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Preclinical models of COPD: a state of the art review.The European respiratory journal · 2026
    Review
  9. A methodological review of pragmatic designs in acute stroke trials.International journal of stroke : official journal of the International Stroke Society · 2026
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Research and Scholarly Methods: Pragmatic Clinical Trials.Journal of the American College of Clinical Pharmacy : JACCP · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hywel C WilliamsCentre of Evidence-Based Dermatology, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom. Electronic address: Hywel.williams@nottingham.ac.uk.
Esther Burden-TehCentre of Evidence-Based Dermatology, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom.
Andrew J NunnMedical Research Council Clinical Trials Unit at UCL, Aviation House, London, United Kingdom.

Funding

Department of Health 06/403/51
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Pragmatic Clinical Trials as TopicResearch DesignCost-Benefit AnalysisDoxycyclineHumansPemphigoid, BullousPrednisoloneSteroidsTetracyclineTreatment OutcomeUnited KingdomUnited StatesDoxycyclinePrednisoloneSteroidsTetracycline

Identifiers

PMID25964272

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.