Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2015
Weight Lifting and Physical Function Among Survivors of Breast Cancer: A Post Hoc Analysis of a Randomized Controlled Trial.
Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 9 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Effects of resistance training on breast cancer-related arm lymphedema: a systematic review and dose-response meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Pooled it
- Physical Activity and Health-Related Quality of Life in Women With Breast Cancer: A Meta-Analysis.JNCI cancer spectrum · 2022Pooled it
- Resistance Training in Breast Cancer Survivors: A Systematic Review of Exercise Programs.International journal of environmental research and public health · 2020Pooled it
- Resistance exercise and breast cancer-related lymphedema-a systematic review update and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Pooled it
- Exercise therapies for preventing or treating aromatase inhibitor-induced musculoskeletal symptoms in early breast cancer.The Cochrane database of systematic reviews · 2020Pooled it
- Exercise for reducing falls in people living with and beyond cancer.The Cochrane database of systematic reviews · 2018Pooled it
- Physical activity for women with breast cancer after adjuvant therapy.The Cochrane database of systematic reviews · 2018Pooled it
- Effect of Home- and Community-Based Physical Activity Interventions on Physical Function Among Cancer Survivors: A Systematic Review and Meta-Analysis.Archives of physical medicine and rehabilitation · 2017Pooled it
- Patient-Reported Physical Function Measures in Cancer Clinical Trials.Epidemiologic reviews · 2017Pooled it
- A randomized dose-response trial of aerobic exercise and health-related quality of life in colon cancer survivors.Psycho-oncology · 2018Trial
- Association Between Maximal Bench Press Strength and Isometric Handgrip Strength Among Breast Cancer Survivors.Archives of physical medicine and rehabilitation · 2017Trial
- Can Resistance Training Prevent Breast Cancer-Related Lymphedema? A Systematic Review with Meta-Analysis.Journal of clinical medicine · 2026Review
- Efficacy of a Supervised Exercise Program on Pain, Physical Function, and Quality of Life in Patients With Breast Cancer: Protocol for a Randomized Clinical Trial.JMIR research protocols · 2025Article
- Measures of physical function clarify the prognostic blur of cancer survivorship.Journal of the National Cancer Institute · 2024Article
- Exercise interventions for adults with cancer receiving radiation therapy alone.The Cochrane database of systematic reviews · 2023Review
- Studying the implementation of exercise oncology interventions: a path forward.Translational journal of the American College of Sports Medicine · 2022Article
- Body image, physical activity and psychological health in older female cancer survivors.Journal of geriatric oncology · 2021Article
- Sarcopenia in aging, obesity, and cancer.Translational cancer research · 2020Article
- Implementing Strength after Breast Cancer (SABC) in outpatient rehabilitation clinics: mapping clinician survey data onto key implementation outcomes.Implementation science communications · 2020Article
- Cancer- and Chemotherapy-Induced Musculoskeletal Degradation.JBMR plus · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purposeSurvivors of breast cancer may experience deterioration of physical function. This is important because poor physical function may be associated with premature mortality, injurious falls, bone fracture, and disability. We conducted a post hoc analysis to explore the potential efficacy of slowly progressive weight lifting to reduce the incidence of physical function deterioration among survivors of breast cancer.
methodsBetween October 2005 and August 2008, we conducted a single-blind, 12-month, randomized controlled trial of twice-per-week slowly progressive weight lifting or standard care among 295 survivors of nonmetastatic breast cancer. In this post hoc analysis of data from the Physical Activity and Lymphedema Trial, we examined incident deterioration of physical function after 12 months, defined as a ≥ 10-point decrease in the physical function subscale of the Medical Outcomes Short-Form 36-item questionnaire.
resultsThe proportion of participants who experienced incident physical function deterioration after 12 months was 16.3% (24/147) in the control group and 8.1% (12/148) in the weight lifting group (relative risk, 0.49; 95% CI, 0.25 to 0.96; P = .04). No serious or unexpected adverse events occurred that were related to weight lifting.
conclusionSlowly progressive weight lifting compared with standard care reduced the incidence of physical function deterioration among survivors of breast cancer. These data are hypothesis generating. Future studies should directly compare the efficacy of weight lifting with other modalities of exercise, such as brisk walking, to appropriately inform the development of a confirmatory study designed to preserve physical function among survivors of breast cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.