ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2015
Prediagnostic Sex Steroid Hormones in Relation to Male Breast Cancer Risk.
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In one paragraph
Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41citing papers in PubMed
10.6field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 88 citations in OpenAlex.
- Multiplatform single-cell and spatial transcriptomics reveal sex-specific malignant states and architecture in male breast cancer.Science advances · 2026Article
- Male breast cancer: from extrapolated practice to evidence-based care.The oncologist · 2026Review
- Emerging and accumulating safety signals for the use of estrogen among transgender women.Discover mental health · 2025Review
- Gynecomastia and Its Management In Boys With Partial Androgen Insensitivity Syndrome.The Journal of clinical endocrinology and metabolism · 2025Article
- Quality-of-Life and Oncological Outcomes in Male Breast Cancer: Insights from an Extensive 20-Year Experience.Cancers · 2025Article
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- Trends in incidence, prevalence, and survival of breast cancer in the United Kingdom from 2000 to 2021.Scientific reports · 2024Article
- Gynecologic Care of Black Breast Cancer Survivors.Current breast cancer reports · 2024Article
- Pleomorphic/solid lobular carcinoma of male breast with PALB2 germline mutation: case report and literature review.Pathologica · 2024Review
- Apocrine Breast Cancer With Psammoma Bodies in a Male Patient.HCA healthcare journal of medicine · 2024Article
- Effect of statins and testosterone replacement therapy on incident cardiovascular disease among male hormone-related cancer survivors.Research square · 2023Article
- Single-cell transcriptome analysis indicates fatty acid metabolism-mediated metastasis and immunosuppression in male breast cancer.Nature communications · 2023Article
- Use of weight loss medications in relation with prostate, colorectal and male breast cancers among older men: SEER-Medicare 2007-2015.Journal of cancer research and clinical oncology · 2023Article
- Single-Cell Transcriptional and Epigenetic Profiles of Male Breast Cancer Nominate Salient Cancer-Specific Enhancers.International journal of molecular sciences · 2023Article
- Molecular characteristics of Asian male BRCA-related cancers.Breast cancer research and treatment · 2023Article
- Metformin and testosterone replacement therapy inversely associated with hormone-associated cancers (prostate, colorectal and male breast cancers) among older White and Black men.Clinical endocrinology · 2022Article
- Risk of breast cancer in men in relation to weight change: A national case-control study in England and Wales.International journal of cancer · 2022Article
- Infertility and risk of breast cancer in men: a national case-control study in England and Wales.Breast cancer research : BCR · 2022Article
- Male Breast Cancer: An Updated Review of Epidemiology, Clinicopathology, and Treatment.Journal of oncology · 2022Review
- Obesity and Breast Cancer Risk in Men: A National Case-Control Study in England and Wales.JNCI cancer spectrum · 2021Article
Corrections and comments
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Authors and funding
18 authors at 1 institution in 1 country.
Louise A BrintonLouise A. Brinton, Shannon N. Wood, Roni T. Falk, and Michael B. Cook, National Cancer Institute, Bethesda; Dominick Parisi, Information Management Services, Rockville, MD; Tim J. Key, University of Oxford, Oxford; Elio Riboli, Imperial College School of Public Health, London, United Kingdom; Laurence N. Kolonel, University of Hawaii, Honolulu, HI; Karin B. Michels, Harvard Medical School and Harvard School of Public Health; Karin B. Michels and Howard D. Sesso, Brigham and Women's Hospital, Boston, MA; Giske Ursin, University of Oslo; Giske Ursin and Elisabete Weiderpass, Cancer Registry of Norway, Oslo; University of Tromsø-Arctic University of Norway, Tromsø, Norway; Karolinska Institutet, Stockholm, Sweden; and Samfundet Folkhalsan, Helsinki, Finland; Giske Ursin, University of Southern California, Los Angeles; Stephen K. Van Den Eeden and Laurel A. Habel, Kaiser Permanente Northern California, Oakland, CA; Chantal Guillemette, Patrick Caron, and Véronique Turcotte, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Québec, Canada; and Claudine J. Isaacs, Georgetown University, Washington, DC. brinton@nih.gov.
Tim J KeyLouise A. Brinton, Shannon N. Wood, Roni T. Falk, and Michael B. Cook, National Cancer Institute, Bethesda; Dominick Parisi, Information Management Services, Rockville, MD; Tim J. Key, University of Oxford, Oxford; Elio Riboli, Imperial College School of Public Health, London, United Kingdom; Laurence N. Kolonel, University of Hawaii, Honolulu, HI; Karin B. Michels, Harvard Medical School and Harvard School of Public Health; Karin B. Michels and Howard D. Sesso, Brigham and Women's Hospital, Boston, MA; Giske Ursin, University of Oslo; Giske Ursin and Elisabete Weiderpass, Cancer Registry of Norway, Oslo; University of Tromsø-Arctic University of Norway, Tromsø, Norway; Karolinska Institutet, Stockholm, Sweden; and Samfundet Folkhalsan, Helsinki, Finland; Giske Ursin, University of Southern California, Los Angeles; Stephen K. Van Den Eeden and Laurel A. Habel, Kaiser Permanente Northern California, Oakland, CA; Chantal Guillemette, Patrick Caron, and Véronique Turcotte, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Québec, Canada; and Claudine J. Isaacs, Georgetown University, Washington, DC.
Laurence N KolonelLouise A. Brinton, Shannon N. Wood, Roni T. Falk, and Michael B. Cook, National Cancer Institute, Bethesda; Dominick Parisi, Information Management Services, Rockville, MD; Tim J. Key, University of Oxford, Oxford; Elio Riboli, Imperial College School of Public Health, London, United Kingdom; Laurence N. Kolonel, University of Hawaii, Honolulu, HI; Karin B. Michels, Harvard Medical School and Harvard School of Public Health; Karin B. Michels and Howard D. Sesso, Brigham and Women's Hospital, Boston, MA; Giske Ursin, University of Oslo; Giske Ursin and Elisabete Weiderpass, Cancer Registry of Norway, Oslo; University of Tromsø-Arctic University of Norway, Tromsø, Norway; Karolinska Institutet, Stockholm, Sweden; and Samfundet Folkhalsan, Helsinki, Finland; Giske Ursin, University of Southern California, Los Angeles; Stephen K. Van Den Eeden and Laurel A. Habel, Kaiser Permanente Northern California, Oakland, CA; Chantal Guillemette, Patrick Caron, and Véronique Turcotte, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Québec, Canada; and Claudine J. Isaacs, Georgetown University, Washington, DC.
Karin B MichelsLouise A. Brinton, Shannon N. Wood, Roni T. Falk, and Michael B. Cook, National Cancer Institute, Bethesda; Dominick Parisi, Information Management Services, Rockville, MD; Tim J. Key, University of Oxford, Oxford; Elio Riboli, Imperial College School of Public Health, London, United Kingdom; Laurence N. Kolonel, University of Hawaii, Honolulu, HI; Karin B. Michels, Harvard Medical School and Harvard School of Public Health; Karin B. Michels and Howard D. Sesso, Brigham and Women's Hospital, Boston, MA; Giske Ursin, University of Oslo; Giske Ursin and Elisabete Weiderpass, Cancer Registry of Norway, Oslo; University of Tromsø-Arctic University of Norway, Tromsø, Norway; Karolinska Institutet, Stockholm, Sweden; and Samfundet Folkhalsan, Helsinki, Finland; Giske Ursin, University of Southern California, Los Angeles; Stephen K. Van Den Eeden and Laurel A. Habel, Kaiser Permanente Northern California, Oakland, CA; Chantal Guillemette, Patrick Caron, and Véronique Turcotte, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Québec, Canada; and Claudine J. Isaacs, Georgetown University, Washington, DC.
Howard D SessoLouise A. Brinton, Shannon N. Wood, Roni T. Falk, and Michael B. Cook, National Cancer Institute, Bethesda; Dominick Parisi, Information Management Services, Rockville, MD; Tim J. Key, University of Oxford, Oxford; Elio Riboli, Imperial College School of Public Health, London, United Kingdom; Laurence N. Kolonel, University of Hawaii, Honolulu, HI; Karin B. Michels, Harvard Medical School and Harvard School of Public Health; Karin B. Michels and Howard D. Sesso, Brigham and Women's Hospital, Boston, MA; Giske Ursin, University of Oslo; Giske Ursin and Elisabete Weiderpass, Cancer Registry of Norway, Oslo; University of Tromsø-Arctic University of Norway, Tromsø, Norway; Karolinska Institutet, Stockholm, Sweden; and Samfundet Folkhalsan, Helsinki, Finland; Giske Ursin, University of Southern California, Los Angeles; Stephen K. Van Den Eeden and Laurel A. Habel, Kaiser Permanente Northern California, Oakland, CA; Chantal Guillemette, Patrick Caron, and Véronique Turcotte, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Québec, Canada; and Claudine J. Isaacs, Georgetown University, Washington, DC.
Giske UrsinLouise A. Brinton, Shannon N. Wood, Roni T. Falk, and Michael B. Cook, National Cancer Institute, Bethesda; Dominick Parisi, Information Management Services, Rockville, MD; Tim J. Key, University of Oxford, Oxford; Elio Riboli, Imperial College School of Public Health, London, United Kingdom; Laurence N. Kolonel, University of Hawaii, Honolulu, HI; Karin B. Michels, Harvard Medical School and Harvard School of Public Health; Karin B. Michels and Howard D. Sesso, Brigham and Women's Hospital, Boston, MA; Giske Ursin, University of Oslo; Giske Ursin and Elisabete Weiderpass, Cancer Registry of Norway, Oslo; University of Tromsø-Arctic University of Norway, Tromsø, Norway; Karolinska Institutet, Stockholm, Sweden; and Samfundet Folkhalsan, Helsinki, Finland; Giske Ursin, University of Southern California, Los Angeles; Stephen K. Van Den Eeden and Laurel A. Habel, Kaiser Permanente Northern California, Oakland, CA; Chantal Guillemette, Patrick Caron, and Véronique Turcotte, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Québec, Canada; and Claudine J. Isaacs, Georgetown University, Washington, DC.
Stephen K Van Den EedenLouise A. Brinton, Shannon N. Wood, Roni T. Falk, and Michael B. Cook, National Cancer Institute, Bethesda; Dominick Parisi, Information Management Services, Rockville, MD; Tim J. Key, University of Oxford, Oxford; Elio Riboli, Imperial College School of Public Health, London, United Kingdom; Laurence N. Kolonel, University of Hawaii, Honolulu, HI; Karin B. Michels, Harvard Medical School and Harvard School of Public Health; Karin B. Michels and Howard D. Sesso, Brigham and Women's Hospital, Boston, MA; Giske Ursin, University of Oslo; Giske Ursin and Elisabete Weiderpass, Cancer Registry of Norway, Oslo; University of Tromsø-Arctic University of Norway, Tromsø, Norway; Karolinska Institutet, Stockholm, Sweden; and Samfundet Folkhalsan, Helsinki, Finland; Giske Ursin, University of Southern California, Los Angeles; Stephen K. Van Den Eeden and Laurel A. Habel, Kaiser Permanente Northern California, Oakland, CA; Chantal Guillemette, Patrick Caron, and Véronique Turcotte, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Québec, Canada; and Claudine J. Isaacs, Georgetown University, Washington, DC.
Shannon N WoodLouise A. Brinton, Shannon N. Wood, Roni T. Falk, and Michael B. Cook, National Cancer Institute, Bethesda; Dominick Parisi, Information Management Services, Rockville, MD; Tim J. Key, University of Oxford, Oxford; Elio Riboli, Imperial College School of Public Health, London, United Kingdom; Laurence N. Kolonel, University of Hawaii, Honolulu, HI; Karin B. Michels, Harvard Medical School and Harvard School of Public Health; Karin B. Michels and Howard D. Sesso, Brigham and Women's Hospital, Boston, MA; Giske Ursin, University of Oslo; Giske Ursin and Elisabete Weiderpass, Cancer Registry of Norway, Oslo; University of Tromsø-Arctic University of Norway, Tromsø, Norway; Karolinska Institutet, Stockholm, Sweden; and Samfundet Folkhalsan, Helsinki, Finland; Giske Ursin, University of Southern California, Los Angeles; Stephen K. Van Den Eeden and Laurel A. Habel, Kaiser Permanente Northern California, Oakland, CA; Chantal Guillemette, Patrick Caron, and Véronique Turcotte, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Québec, Canada; and Claudine J. Isaacs, Georgetown University, Washington, DC.
Roni T FalkLouise A. Brinton, Shannon N. Wood, Roni T. Falk, and Michael B. Cook, National Cancer Institute, Bethesda; Dominick Parisi, Information Management Services, Rockville, MD; Tim J. Key, University of Oxford, Oxford; Elio Riboli, Imperial College School of Public Health, London, United Kingdom; Laurence N. Kolonel, University of Hawaii, Honolulu, HI; Karin B. Michels, Harvard Medical School and Harvard School of Public Health; Karin B. Michels and Howard D. Sesso, Brigham and Women's Hospital, Boston, MA; Giske Ursin, University of Oslo; Giske Ursin and Elisabete Weiderpass, Cancer Registry of Norway, Oslo; University of Tromsø-Arctic University of Norway, Tromsø, Norway; Karolinska Institutet, Stockholm, Sweden; and Samfundet Folkhalsan, Helsinki, Finland; Giske Ursin, University of Southern California, Los Angeles; Stephen K. Van Den Eeden and Laurel A. Habel, Kaiser Permanente Northern California, Oakland, CA; Chantal Guillemette, Patrick Caron, and Véronique Turcotte, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Québec, Canada; and Claudine J. Isaacs, Georgetown University, Washington, DC.
Dominick ParisiLouise A. Brinton, Shannon N. Wood, Roni T. Falk, and Michael B. Cook, National Cancer Institute, Bethesda; Dominick Parisi, Information Management Services, Rockville, MD; Tim J. Key, University of Oxford, Oxford; Elio Riboli, Imperial College School of Public Health, London, United Kingdom; Laurence N. Kolonel, University of Hawaii, Honolulu, HI; Karin B. Michels, Harvard Medical School and Harvard School of Public Health; Karin B. Michels and Howard D. Sesso, Brigham and Women's Hospital, Boston, MA; Giske Ursin, University of Oslo; Giske Ursin and Elisabete Weiderpass, Cancer Registry of Norway, Oslo; University of Tromsø-Arctic University of Norway, Tromsø, Norway; Karolinska Institutet, Stockholm, Sweden; and Samfundet Folkhalsan, Helsinki, Finland; Giske Ursin, University of Southern California, Los Angeles; Stephen K. Van Den Eeden and Laurel A. Habel, Kaiser Permanente Northern California, Oakland, CA; Chantal Guillemette, Patrick Caron, and Véronique Turcotte, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Québec, Canada; and Claudine J. Isaacs, Georgetown University, Washington, DC.
Chantal GuillemetteLouise A. Brinton, Shannon N. Wood, Roni T. Falk, and Michael B. Cook, National Cancer Institute, Bethesda; Dominick Parisi, Information Management Services, Rockville, MD; Tim J. Key, University of Oxford, Oxford; Elio Riboli, Imperial College School of Public Health, London, United Kingdom; Laurence N. Kolonel, University of Hawaii, Honolulu, HI; Karin B. Michels, Harvard Medical School and Harvard School of Public Health; Karin B. Michels and Howard D. Sesso, Brigham and Women's Hospital, Boston, MA; Giske Ursin, University of Oslo; Giske Ursin and Elisabete Weiderpass, Cancer Registry of Norway, Oslo; University of Tromsø-Arctic University of Norway, Tromsø, Norway; Karolinska Institutet, Stockholm, Sweden; and Samfundet Folkhalsan, Helsinki, Finland; Giske Ursin, University of Southern California, Los Angeles; Stephen K. Van Den Eeden and Laurel A. Habel, Kaiser Permanente Northern California, Oakland, CA; Chantal Guillemette, Patrick Caron, and Véronique Turcotte, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Québec, Canada; and Claudine J. Isaacs, Georgetown University, Washington, DC.
Patrick CaronLouise A. Brinton, Shannon N. Wood, Roni T. Falk, and Michael B. Cook, National Cancer Institute, Bethesda; Dominick Parisi, Information Management Services, Rockville, MD; Tim J. Key, University of Oxford, Oxford; Elio Riboli, Imperial College School of Public Health, London, United Kingdom; Laurence N. Kolonel, University of Hawaii, Honolulu, HI; Karin B. Michels, Harvard Medical School and Harvard School of Public Health; Karin B. Michels and Howard D. Sesso, Brigham and Women's Hospital, Boston, MA; Giske Ursin, University of Oslo; Giske Ursin and Elisabete Weiderpass, Cancer Registry of Norway, Oslo; University of Tromsø-Arctic University of Norway, Tromsø, Norway; Karolinska Institutet, Stockholm, Sweden; and Samfundet Folkhalsan, Helsinki, Finland; Giske Ursin, University of Southern California, Los Angeles; Stephen K. Van Den Eeden and Laurel A. Habel, Kaiser Permanente Northern California, Oakland, CA; Chantal Guillemette, Patrick Caron, and Véronique Turcotte, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Québec, Canada; and Claudine J. Isaacs, Georgetown University, Washington, DC.
Véronique TurcotteLouise A. Brinton, Shannon N. Wood, Roni T. Falk, and Michael B. Cook, National Cancer Institute, Bethesda; Dominick Parisi, Information Management Services, Rockville, MD; Tim J. Key, University of Oxford, Oxford; Elio Riboli, Imperial College School of Public Health, London, United Kingdom; Laurence N. Kolonel, University of Hawaii, Honolulu, HI; Karin B. Michels, Harvard Medical School and Harvard School of Public Health; Karin B. Michels and Howard D. Sesso, Brigham and Women's Hospital, Boston, MA; Giske Ursin, University of Oslo; Giske Ursin and Elisabete Weiderpass, Cancer Registry of Norway, Oslo; University of Tromsø-Arctic University of Norway, Tromsø, Norway; Karolinska Institutet, Stockholm, Sweden; and Samfundet Folkhalsan, Helsinki, Finland; Giske Ursin, University of Southern California, Los Angeles; Stephen K. Van Den Eeden and Laurel A. Habel, Kaiser Permanente Northern California, Oakland, CA; Chantal Guillemette, Patrick Caron, and Véronique Turcotte, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Québec, Canada; and Claudine J. Isaacs, Georgetown University, Washington, DC.
Laurel A HabelLouise A. Brinton, Shannon N. Wood, Roni T. Falk, and Michael B. Cook, National Cancer Institute, Bethesda; Dominick Parisi, Information Management Services, Rockville, MD; Tim J. Key, University of Oxford, Oxford; Elio Riboli, Imperial College School of Public Health, London, United Kingdom; Laurence N. Kolonel, University of Hawaii, Honolulu, HI; Karin B. Michels, Harvard Medical School and Harvard School of Public Health; Karin B. Michels and Howard D. Sesso, Brigham and Women's Hospital, Boston, MA; Giske Ursin, University of Oslo; Giske Ursin and Elisabete Weiderpass, Cancer Registry of Norway, Oslo; University of Tromsø-Arctic University of Norway, Tromsø, Norway; Karolinska Institutet, Stockholm, Sweden; and Samfundet Folkhalsan, Helsinki, Finland; Giske Ursin, University of Southern California, Los Angeles; Stephen K. Van Den Eeden and Laurel A. Habel, Kaiser Permanente Northern California, Oakland, CA; Chantal Guillemette, Patrick Caron, and Véronique Turcotte, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Québec, Canada; and Claudine J. Isaacs, Georgetown University, Washington, DC.
Claudine J IsaacsLouise A. Brinton, Shannon N. Wood, Roni T. Falk, and Michael B. Cook, National Cancer Institute, Bethesda; Dominick Parisi, Information Management Services, Rockville, MD; Tim J. Key, University of Oxford, Oxford; Elio Riboli, Imperial College School of Public Health, London, United Kingdom; Laurence N. Kolonel, University of Hawaii, Honolulu, HI; Karin B. Michels, Harvard Medical School and Harvard School of Public Health; Karin B. Michels and Howard D. Sesso, Brigham and Women's Hospital, Boston, MA; Giske Ursin, University of Oslo; Giske Ursin and Elisabete Weiderpass, Cancer Registry of Norway, Oslo; University of Tromsø-Arctic University of Norway, Tromsø, Norway; Karolinska Institutet, Stockholm, Sweden; and Samfundet Folkhalsan, Helsinki, Finland; Giske Ursin, University of Southern California, Los Angeles; Stephen K. Van Den Eeden and Laurel A. Habel, Kaiser Permanente Northern California, Oakland, CA; Chantal Guillemette, Patrick Caron, and Véronique Turcotte, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Québec, Canada; and Claudine J. Isaacs, Georgetown University, Washington, DC.
Elio RiboliLouise A. Brinton, Shannon N. Wood, Roni T. Falk, and Michael B. Cook, National Cancer Institute, Bethesda; Dominick Parisi, Information Management Services, Rockville, MD; Tim J. Key, University of Oxford, Oxford; Elio Riboli, Imperial College School of Public Health, London, United Kingdom; Laurence N. Kolonel, University of Hawaii, Honolulu, HI; Karin B. Michels, Harvard Medical School and Harvard School of Public Health; Karin B. Michels and Howard D. Sesso, Brigham and Women's Hospital, Boston, MA; Giske Ursin, University of Oslo; Giske Ursin and Elisabete Weiderpass, Cancer Registry of Norway, Oslo; University of Tromsø-Arctic University of Norway, Tromsø, Norway; Karolinska Institutet, Stockholm, Sweden; and Samfundet Folkhalsan, Helsinki, Finland; Giske Ursin, University of Southern California, Los Angeles; Stephen K. Van Den Eeden and Laurel A. Habel, Kaiser Permanente Northern California, Oakland, CA; Chantal Guillemette, Patrick Caron, and Véronique Turcotte, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Québec, Canada; and Claudine J. Isaacs, Georgetown University, Washington, DC.
Elisabete WeiderpassLouise A. Brinton, Shannon N. Wood, Roni T. Falk, and Michael B. Cook, National Cancer Institute, Bethesda; Dominick Parisi, Information Management Services, Rockville, MD; Tim J. Key, University of Oxford, Oxford; Elio Riboli, Imperial College School of Public Health, London, United Kingdom; Laurence N. Kolonel, University of Hawaii, Honolulu, HI; Karin B. Michels, Harvard Medical School and Harvard School of Public Health; Karin B. Michels and Howard D. Sesso, Brigham and Women's Hospital, Boston, MA; Giske Ursin, University of Oslo; Giske Ursin and Elisabete Weiderpass, Cancer Registry of Norway, Oslo; University of Tromsø-Arctic University of Norway, Tromsø, Norway; Karolinska Institutet, Stockholm, Sweden; and Samfundet Folkhalsan, Helsinki, Finland; Giske Ursin, University of Southern California, Los Angeles; Stephen K. Van Den Eeden and Laurel A. Habel, Kaiser Permanente Northern California, Oakland, CA; Chantal Guillemette, Patrick Caron, and Véronique Turcotte, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Québec, Canada; and Claudine J. Isaacs, Georgetown University, Washington, DC.
Michael B CookLouise A. Brinton, Shannon N. Wood, Roni T. Falk, and Michael B. Cook, National Cancer Institute, Bethesda; Dominick Parisi, Information Management Services, Rockville, MD; Tim J. Key, University of Oxford, Oxford; Elio Riboli, Imperial College School of Public Health, London, United Kingdom; Laurence N. Kolonel, University of Hawaii, Honolulu, HI; Karin B. Michels, Harvard Medical School and Harvard School of Public Health; Karin B. Michels and Howard D. Sesso, Brigham and Women's Hospital, Boston, MA; Giske Ursin, University of Oslo; Giske Ursin and Elisabete Weiderpass, Cancer Registry of Norway, Oslo; University of Tromsø-Arctic University of Norway, Tromsø, Norway; Karolinska Institutet, Stockholm, Sweden; and Samfundet Folkhalsan, Helsinki, Finland; Giske Ursin, University of Southern California, Los Angeles; Stephen K. Van Den Eeden and Laurel A. Habel, Kaiser Permanente Northern California, Oakland, CA; Chantal Guillemette, Patrick Caron, and Véronique Turcotte, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Québec, Canada; and Claudine J. Isaacs, Georgetown University, Washington, DC.
Harvard University · US
Funding
Studies of Rare CancersZIACP010158 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI MCGLYNN, KATHERINE · 2009 to 2025
$19.1MPhysicians' Health Study II: Prevention Trial of VitaminsR01CA097193 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI GAZIANO, J. MICHAEL · 2002 to 2011
$15.7MCancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5MRANDOMIZED TRIAL OF ASPIRIN AND MORTALITYR01CA040360 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E · 1985 to 2002
$775kTRIAL OF ASPIRIN AND BETA-CAROTENE IN U S MD'SR01HL034595 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E · 1985 to 1991
–Cancer Research UK 16491Medical Research CouncilNCI NIH HHS CA097193NCI NIH HHS CA40360NCI NIH HHS R01 CA034944NCI NIH HHS R01 CA040360NCI NIH HHS R01 CA097193NCI NIH HHS UM1 CA167552NHLBI NIH HHS R01 HL026490NHLBI NIH HHS R01 HL034595
Abstract
purposeAlthough previous studies have implicated a variety of hormone-related risk factors in the etiology of male breast cancers, no previous studies have examined the effects of endogenous hormones. PATIENTS AND
methodsWithin the Male Breast Cancer Pooling Project, an international consortium comprising 21 case-control and cohort investigations, a subset of seven prospective cohort studies were able to contribute prediagnostic serum or plasma samples for hormone quantitation. Using a nested case-control design, multivariable unconditional logistic regression analyses estimated odds ratios and 95% CIs for associations between male breast cancer risk and 11 individual estrogens and androgens, as well as selected ratios of these analytes.
resultsData from 101 cases and 217 matched controls were analyzed. After adjustment for age and date of blood draw, race, and body mass index, androgens were found to be largely unrelated to risk, but circulating estradiol levels showed a significant association. Men in the highest quartile had an odds ratio of 2.47 (95% CI, 1.10 to 5.58) compared with those in the lowest quartile (trend P = .06). Assessment of estradiol as a ratio to various individual androgens or sum of androgens showed no further enhancement of risk. These relations were not significantly modified by either age or body mass index, although estradiol was slightly more strongly related to breast cancers occurring among younger (age < 67 years) than older men.
conclusionOur results support the notion of an important role for estradiol in the etiology of male breast cancers, similar to female breast cancers.
Indexed as
AgedAndrogensBreast Neoplasms, MaleCase-Control StudiesCohort StudiesEstradiolGonadal Steroid HormonesHormonesHumansInternational CooperationMaleMiddle AgedMultivariate AnalysisOdds RatioRisk FactorsAndrogensEstradiolGonadal Steroid HormonesHormones
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