ArticleReproductive sciences (Thousand Oaks, Calif.)2015
Expression of Interferon γ by Decidual Cells and Natural Killer Cells at the Human Implantation Site: Implications for Preeclampsia, Spontaneous Abortion, and Intrauterine Growth Restriction.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Fractalkine (Chemokine CX3CL1) Signaling During Placentation and Placental Function.International journal of molecular sciences · 2026Review
- Aberrant NK cell profile in gestational diabetes mellitus with fetal growth restriction.Frontiers in immunology · 2024Article
- Relationship of interferon regulator factor 5 and interferon-γ with missed abortion.Experimental and therapeutic medicine · 2022Article
- HMGA1 Is a Potential Driver of Preeclampsia Pathogenesis by Interference with Extravillous Trophoblasts Invasion.Biomolecules · 2021Review
- How Do Uterine Natural Killer and Innate Lymphoid Cells Contribute to Successful Pregnancy?Frontiers in immunology · 2021Review
- Is there an inflammatory stimulus to human term labour?PloS one · 2021Article
- Uvaol Prevents Group BFrontiers in physiology · 2021Article
- Immunological adaptations in pregnancy that modulate rheumatoid arthritis disease activity.Nature reviews. Rheumatology · 2020Review
- Immune Cells in the Uterine Remodeling: Are They the Target of Endocrine Disrupting Chemicals?Frontiers in immunology · 2020Review
- Regulation of CX3CL1 Expression in Human First-Trimester Decidual Cells: Implications for Preeclampsia.Reproductive sciences (Thousand Oaks, Calif.) · 2019Article
- RBPJ mediates uterine repair in the mouse and is reduced in women with recurrent pregnancy loss.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- hCG: Biological Functions and Clinical Applications.International journal of molecular sciences · 2017Review
- Early first trimester peripheral blood cell microRNA predicts risk of preterm delivery in pregnant women: Proof of concept.PloS one · 2017Article
- Colorectal cancer and theGenomics data · 2016Article
- The role of decidual cells in uterine hemostasis, menstruation, inflammation, adverse pregnancy outcomes and abnormal uterine bleeding.Human reproduction update · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Human first-trimester decidual cells (FTDCs) chemoattract CXCR3-expressing circulating CD56(bright)CD16(-) natural killer (NK) cells, which increase uteroplacental blood flow by remodeling spiral arteries and arterioles. This recruitment reflects elevated FTDC expression of NK cell-recruiting induced protein 10 and interferon (IFN)-inducible T-cell-α chemoattractant produced in response to the synergistic effects of tumor necrosis factor α (TNF-α) and IFN-γ stimulation. Decidual macrophages express TNF-α, whereas the cellular origin of IFN-γ is unclear. Therefore, this study aims to identify the cell source(s) of IFN-γ in human first trimester decidua. Immunostaining of decidual sections revealed that both FTDCs and decidual NK (dNK) cells express IFN-γ. Although individual dNK cells express higher IFN-γ levels, the more numerous FTDCs account for greater proportion of total IFN-γ immunostaining. Freshly isolated FTDCs express greater IFN-γ staining than dNK cells as measured by flow cytometry, whereas incubation of dNK cells with documented NK cell activators significantly increases IFN-γ above FTDC levels. Confluent FTDCs intrinsically produce, but paradoxically respond to, exogenous IFN-γ.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.