Evidence map›Paper›PMID 25963897›Full record

ArticleJournal of medical primatology2015

Heterospecific SNP diversity in humans and rhesus macaque (Macaca mulatta).

Jillian Ng, Jessica Satkoski Trask, David Glenn Smith, Sree Kanthaswamy

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical primatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Choroidal Changes in Rhesus Macaques in Aging and Age-Related Drusen.Investigative ophthalmology & visual science · 2023
    Article
  2. Article
  3. Comparative medicine · 2020
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jillian NgMolecular Anthropology Laboratory, Department of Anthropology, University of California, Davis, CA, USA.
Jessica Satkoski TraskMolecular Anthropology Laboratory, Department of Anthropology, University of California, Davis, CA, USA.
David Glenn SmithMolecular Anthropology Laboratory, Department of Anthropology, University of California, Davis, CA, USA.
Sree KanthaswamyMolecular Anthropology Laboratory, Department of Anthropology, University of California, Davis, CA, USA.
University of California, Davis · USMaricopa Community Colleges - Glendale Community College · US

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
ZONA PELLUCIDA PEPTIDES AS IMMUNOCONTRACEPTIVE ANTIGENSP51RR000169 · NCRR · UNIVERSITY OF CALIFORNIA DAVIS · PI HORTON, JONATHON C · 1985 to 2011
$126.2M
GENETICALLY DEFINED HERPES/RETROVIRUS SPF MACAQUES: AIDS: VACCINE DVMTU24RR018144 · NCRR · UNIVERSITY OF CALIFORNIA DAVIS · PI LERCHE, NICHOLAS WILLIAM · 2002 to 2011
$15.7M
GENETIC MANAGEMENT OF MECAQUES BY DNA RFLP ANALYSISR24RR005090 · NCRR · UNIVERSITY OF CALIFORNIA DAVIS · PI SMITH, DAVID GLENN · 1988 to 2011
$3.7M
Development, Management and Use of a SNP Map for Rhesus MacaqueR24RR025871 · NCRR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SMITH, DAVID GLENN · 2009 to 2011
$1.6M
NCRR NIH HHS P51 RR000169NCRR NIH HHS R24 RR005090NCRR NIH HHS R24 RR025871NCRR NIH HHS RR000169-48NCRR NIH HHS RR005090NCRR NIH HHS RR018144-07NCRR NIH HHS RR025871NCRR NIH HHS U24 RR018144NIH HHS P51 OD011107
6 · The paper itself

Abstract

backgroundConservation of single nucleotide polymorphisms (SNPs) between human and other primates (i.e., heterospecific SNPs) in candidate genes can be used to assess the utility of those organisms as models for human biomedical research.

methodsA total of 59,691 heterospecific SNPs in 22 rhesus macaques and 20 humans were analyzed for human trait associations and 4207 heterospecific SNPs biallelic in both taxa were compared for genetic variation.

resultsVariation comparisons at the 4207 SNPs showed that humans were more genetically diverse than rhesus macaques with observed and expected heterozygosities of 0.337 and 0.323 vs. 0.119 and 0.102, and minor allele frequencies of 0.239 and 0.063, respectively. In total, 431 of the 59,691 heterospecific SNPs are reportedly associated with human-specific traits.

conclusionWhile comparisons between human and rhesus macaque genomes are plausible, functional studies of heterospecific SNPs are necessary to determine whether rhesus macaque alleles are associated with the same phenotypes as their corresponding human alleles.

Indexed as

AnimalsGene FrequencyGenetic VariationHeterozygoteHumansMacaca mulattaPolymorphism, Single NucleotideSpecies Specificitygenomic comparisonHomo sapiensnon-human primatesorthologs

Identifiers

PMID25963897
PMCPMC5930483
OpenAlexW2149695822

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.