ArticleMolecular & cellular proteomics : MCP2015
Global Proteomics Analysis of the Response to Starvation in C. elegans.
Article in Molecular & cellular proteomics : MCP, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Detecting gene expression in Caenorhabditis elegans.Genetics · 2025Review
- Single-tissue proteomics inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Starvation resistance in the nematode Pristionchus pacificus requires a conserved supplementary nuclear receptor.Zoological letters · 2024Article
- The protein tyrosine phosphatase PPH-7 is required for fertility and embryonic development in C. elegans at elevated temperatures.FEBS open bio · 2024Article
- Stress increases in exopher-mediated neuronal extrusion require lipid biosynthesis, FGF, and EGF RAS/MAPK signaling.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- DehydratedG3 (Bethesda, Md.) · 2020Article
- Starvation Responses Throughout theGenetics · 2020Review
- NHR-49 Transcription Factor Regulates Immunometabolic Response and Survival of Caenorhabditis elegans during Enterococcus faecalis Infection.Infection and immunity · 2020Article
- Analysis of Lifespan in C. elegans: Low- and High-Throughput Approaches.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Dietary restriction and gonadal signaling differentially regulate post-development quality control functions in Caenorhabditis elegans.Aging cell · 2019Article
- Article
- The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan.Journal of visualized experiments : JoVE · 2018Article
- The Encyclopedia of Proteome Dynamics: a big data ecosystem for (prote)omics.Nucleic acids research · 2018Article
- Omics Approaches for Identifying Physiological Adaptations to Genome Instability in Aging.International journal of molecular sciences · 2017Review
- Article
- Degradation of protein translation machinery by amino acid starvation-induced macroautophagy.Autophagy · 2017Article
- The Profile and Dynamics of RNA Modifications in Animals.Chembiochem : a European journal of chemical biology · 2017Article
- Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans.PLoS genetics · 2017Article
- Global Proteomics RevealedFrontiers in cellular and infection microbiology · 2017Article
- Micro-proteomics with iterative data analysis: Proteome analysis in C. elegans at the single worm level.Proteomics · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Periodic starvation of animals induces large shifts in metabolism but may also influence many other cellular systems and can lead to adaption to prolonged starvation conditions. To date, there is limited understanding of how starvation affects gene expression, particularly at the protein level. Here, we have used mass-spectrometry-based quantitative proteomics to identify global changes in the Caenorhabditis elegans proteome due to acute starvation of young adult animals. Measuring changes in the abundance of over 5,000 proteins, we show that acute starvation rapidly alters the levels of hundreds of proteins, many involved in central metabolic pathways, highlighting key regulatory responses. Surprisingly, we also detect changes in the abundance of chromatin-associated proteins, including specific linker histones, histone variants, and histone posttranslational modifications associated with the epigenetic control of gene expression. To maximize community access to these data, they are presented in an online searchable database, the Encyclopedia of Proteome Dynamics (http://www.peptracker.com/epd/).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.