Evidence map›Paper›PMID 25963591›Full record

ReviewNature reviews. Nephrology2015

Microbiota—implications for immunity and transplantation.

Jonathan S Bromberg, W Florian Fricke, C Colin Brinkman, Thomas Simon, Emmanuel F Mongodin

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Nephrology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Synbiotics, prebiotics and probiotics for solid organ transplant recipients.The Cochrane database of systematic reviews · 2022
    Pooled it
  3. Article
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  15. Evidence-based complementary and alternative medicine : eCAM · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Jonathan S BrombergDepartments of Surgery, Microbiology, and Immunology, University of Maryland School of Medicine, Center for Vascular and Inflammatory Diseases, 29 South Greene Street, Baltimore, MD 21201, USA.
W Florian FrickeInstitute of Biological Chemistry and Nutrition, University of Hohenheim, Gardenstrasse 30, Stuttgart 70593, Germany.
C Colin BrinkmanDepartment of Surgery, Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, 801 West Baltimore Street, Baltimore, MD 21201, USA.
Thomas SimonDepartment of Surgery, Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, 801 West Baltimore Street, Baltimore, MD 21201, USA.
Emmanuel F MongodinInstitute for Genome Sciences, University of Maryland School of Medicine, 802 West Baltimore Street, Baltimore, MD 21201, USA.
University of Maryland, Baltimore · USUniversity of Hohenheim · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Each individual harbours a unique set of commensal microorganisms, collectively referred to as the microbiota. Notably, these microorganisms exceed the number of cells in the human body by 10-fold. This finding has accelerated a shift in our understanding of human physiology, with the realization that traits necessary for health are both encoded and influenced by the human genome and the microbiota. Our understanding of the aetiology of complex diseases has, therefore, evolved with increasing awareness that the human microbiota has an active and critical role in maintaining health and inducing disease. Indeed, findings from bioinformatic studies indicate that the microbiota and microbiome have multiple effects on the innate and adaptive immune systems, with effects on infection, autoimmune disease and cancer. In this Review, we first address the important statistical and informatics aspects that should be considered when characterizing the composition of microbiota. We next highlight the effects of the microbiota on the immune system and the implications of these effects on organ failure and transplantation. Finally, we reflect on the future perspectives for studies of the microbiota, including novel diagnostic tests and therapeutics.

Indexed as

Transplantation ImmunologyAdaptive ImmunityComputational BiologyHumansImmunity, InnateMicrobiotaRNA, Ribosomal, 16SRNA, Ribosomal, 16S

Identifiers

PMID25963591
OpenAlexW1558591677

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.