ArticlePsychopharmacology2015
Exposure to psychotropic medications prior to overdose: a case-control study.
Article in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Qualitative analysis of blood from patients engaging in deliberate self-harm: Differences between prescribed and detected drugs.Neuropsychopharmacology reports · 2024Article
- Creating and evaluating the score to assess overdose: the OD score.BMC emergency medicine · 2024Article
- Factors associated with long-term benzodiazepine and Z-drug use across the lifespan and 5-year temporal trajectories among incident users: a Swedish nationwide register-based study.European journal of clinical pharmacology · 2023Article
- Suicidal attempts and self-poisoning: 1-year retrospective cohort study from the quaternary hospital in Thai metropolitan area.Health science reports · 2022Article
- Association between psychotropic prescriptions and the total amount of psychotropics ingested during an intentional overdose: A single-center retrospective study.Neuropsychopharmacology reports · 2022Article
- Relationship between tracheal intubation and the drugs used by patients with drug overdose due to self-harm.Journal of pharmaceutical health care and sciences · 2022Article
- Evaluation of factors related to overdose in patients with impaired consciousness who are transported by emergency medical services: an age-specific research.Journal of pharmaceutical health care and sciences · 2021Article
- Pulverizing medication as a harm reduction and intentional drug overdose prevention strategy: Two case studies.Neuropsychopharmacology reports · 2021Article
- Epidemiology of overdose episodes from the period prior to hospitalization for drug poisoning until discharge in Japan: An exploratory descriptive study using a nationwide claims database.Journal of epidemiology · 2017Article
- The Basic Act for Suicide Prevention: Effects on Longitudinal Trend in Deliberate Self-Harm with Reference to National Suicide Data for 1996-2014.International journal of environmental research and public health · 2017Article
- Risk of recurrent overdose associated with prescribing patterns of psychotropic medications after nonfatal overdose.Neuropsychiatric disease and treatment · 2017Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleLittle is known about psychotropic medication prescriptions prior to drug overdose.
objectivesWe aimed to examine the possible associations between the risk of overdose and exposures to various psychotropic medications.
methodsWe conducted a matched case-control study of 3 groups of patients aged 12-74 years, using a large-scale health insurance claims database in Japan (population 1.2 million). A total of 351 cases with drug poisoning were compared with two control groups without overdose: 1755 patients with any treatment (general controls) and those with depression (high-risk controls). Current, past, and nonusers were patients most recently exposed to psychotropic medications ≤ 90 days, 91-180 days, and ≥ 180 days before the index date.
resultsCurrent sedative-hypnotic use was associated with an increased odds of overdose relative to general control nonusers (odds ratio [OR], 21.5; 95 % confidence interval [CI], 9.7-47.8) and high-risk control nonusers (OR, 2.6; 95 % CI, 1.9-3.5). In the comparison of cases and high-risk controls, the ORs for overdose were higher among excessive dosage users than among usual dosage users (OR, 4.3; 95 % CI, 3.0-6.1), among barbiturate users than among benzodiazepine/Z-drug only users (OR, 4.5; 95 % CI, 2.3-8.7), and among multiple provider episodes than among single provider episodes (OR, 4.4; 95 % CI, 1.7-11.0). Psychiatrists prescribed more than 77 % of potentially questionable prescriptions.
conclusionsThese results highlight the need for psychiatrists to monitor prescribed medications and balance the benefits and risks of pharmacological treatments.
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