Evidence map›Paper›PMID 25963309›Full record

ArticleBMC cancer2015

Hyperemesis gravidarum and risk of cancer in offspring, a Scandinavian registry-based nested case-control study.

Kathrine F Vandraas, Åse V Vikanes, Nathalie C Støer, Rebecca Troisi, Olof Stephansson, Henrik T Sørensen, Siri Vangen, Per Magnus, Andrej M Grjibovski, Tom Grotmol

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Observational
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Barriers and Challenges in Hyperemesis Gravidarum Research.Nutrition and metabolic insights · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 6 countries.

Kathrine F VandraasDepartment of Genes and Environment, Norwegian Institute of Public Health, PO Box 4404, Nydalen, 0403, Oslo, Norway. kafv@fhi.no.
Åse V VikanesDepartment of Genes and Environment, Norwegian Institute of Public Health, PO Box 4404, Nydalen, 0403, Oslo, Norway. ase.vigdis.vikanes@fhi.no.
Nathalie C StøerDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. nathalcs@math.uio.no.
Rebecca TroisiDivisions of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 9000 Rockville Pike, Bethesda, MD, 20892, USA. troisir@mail.nih.gov.
Olof StephanssonClinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital and Institute, SE-141 86, Stockholm, Sweden. olof.stephansson@ki.se.
Henrik T SørensenDepartment of Clinical Epidemiology, Aarhus University Hospital, 44 Norrebrogade, 8000, Aarhus, Denmark. hts@clin.au.dk.
Siri VangenNorwegian National Advisory Unit on Women's Health, Oslo University Hospital, PO box 4950, Nydalen, Oslo, Norway. sirvan@ous-hf.no.
Per MagnusDepartment of Genes and Environment, Norwegian Institute of Public Health, PO Box 4404, Nydalen, 0403, Oslo, Norway. per.magnus@fhi.no.
Andrej M GrjibovskiDepartment of International Public Health, Norwegian Institute of Public Health, PO Box 4404, Nydalen, 0403, Oslo, Norway. andrej.grjibovski@gmail.com.
Tom GrotmolCancer Registry of Norway, PO Box 5313, Majorstuen, N-0304, Oslo, Norway. tom.grotmol@kreftregisteret.no.
Norwegian Institute of Public Health · NOKarolinska Institutet · SEAarhus University Hospital · DKCancer Registry of Norway · NONational Institutes of Health · USNorthern State Medical University · RUOslo University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHyperemesis gravidarum is a serious condition affecting 0.8-2.3% of pregnant women and can be regarded as a restricted period of famine. Research concerning potential long-term consequences of the condition for the offspring, is limited, but lack of nutrition in-utero has been associated with chronic disease in adulthood, including some cancers. There is growing evidence that several forms of cancer may originate during fetal life. We conducted a large study linking the high-quality population-based medical birth- and cancer registries in Norway, Sweden and Denmark, to explore whether hyperemesis is associated with increased cancer risk in offspring.

methodsA registry-based nested case-control study. Twelve types of childhood cancer were selected; leukemia, lymphoma, cancer of the central nervous system, testis, bone, ovary, breast, adrenal and thyroid gland, nephroblastoma, hepatoblastoma and retinoblastoma. Conditional logistic regression models were applied to study associations between hyperemesis and risk of childhood cancer, both all types combined and separately. Cancer types with five or more exposed cases were stratified by age at diagnosis. All analysis were adjusted for maternal age, ethnicity and smoking, in addition to the offspring's Apgar score, placental weight and birth weight. Relative risks with 95% confidence intervals were calculated.

resultsIn total 14,805 cases and approximately ten controls matched on time, country of birth, sex and year of birth per case (147,709) were identified. None of the cancer types, analyzed combined or separately, revealed significant association with hyperemesis. When stratified according to age at diagnosis, we observed a RR 2.13 for lymphoma among adolescents aged 11-20 years ((95% CI 1.14-3.99), after adjustment for maternal ethnicity and maternal age, RR 2.08 (95% CI 1.11-3.90)). The finding was not apparent when a stricter level of statistical significance was applied.

conclusionsThe main finding of this paper is that hyperemesis does not seem to increase cancer risk in offspring. The positive association to lymphoma may be by chance and needs confirmation.

Indexed as

AdolescentAdultCase-Control StudiesChildChild, PreschoolFemaleHumansHyperemesis GravidarumInfantInfant, NewbornLymphomaMalePregnancyPrenatal Exposure Delayed EffectsRisk FactorsYoung Adult

Identifiers

PMID25963309
PMCPMC4430929
OpenAlexW1528670593

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.