Evidence map›Paper›PMID 25963157›Full record

ArticleThe neuroradiology journal2015

Brain MR diffusion tensor imaging in Kennedy's disease.

Francesco Garaci, Nicola Toschi, Simona Lanzafame, Girolama A Marfia, Simone Marziali, Alessandro Meschini, Francesca Di Giuliano, Giovanni Simonetti, Maria Guerrisi, Roberto Massa and 1 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The neuroradiology journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Neuroimaging findings in leukoencephalopathy with calcifications and cysts: case report and review of the literature.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Review
  3. Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Francesco GaraciDepartment of Diagnostic Imaging, Molecular Imaging, Interventional Radiology and Radiotherapy, University Hospital Tor Vergata, Italy Department of Biomedicine and Prevention, Faculty of Medicine, University of Rome Tor Vergata, Italy.
Nicola ToschiDepartment of Biomedicine and Prevention, Faculty of Medicine, University of Rome Tor Vergata, Italy Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, USA and Harvard Medical School, USA toschi@med.uniroma2.it.
Simona LanzafameDepartment of Biomedicine and Prevention, Faculty of Medicine, University of Rome Tor Vergata, Italy.
Girolama A MarfiaDepartment of Systems Medicine, Section Neurology, University of Rome Tor Vergata, Italy.
Simone MarzialiDepartment of Diagnostic Imaging, Molecular Imaging, Interventional Radiology and Radiotherapy, University Hospital Tor Vergata, Italy.
Alessandro MeschiniDepartment of Diagnostic Imaging, Molecular Imaging, Interventional Radiology and Radiotherapy, University Hospital Tor Vergata, Italy.
Francesca Di GiulianoDepartment of Diagnostic Imaging, Molecular Imaging, Interventional Radiology and Radiotherapy, University Hospital Tor Vergata, Italy.
Giovanni SimonettiDepartment of Diagnostic Imaging, Molecular Imaging, Interventional Radiology and Radiotherapy, University Hospital Tor Vergata, Italy Department of Biomedicine and Prevention, Faculty of Medicine, University of Rome Tor Vergata, Italy.
Maria GuerrisiDepartment of Biomedicine and Prevention, Faculty of Medicine, University of Rome Tor Vergata, Italy.
Roberto MassaDepartment of Systems Medicine, Section Neurology, University of Rome Tor Vergata, Italy.
Roberto FlorisDepartment of Diagnostic Imaging, Molecular Imaging, Interventional Radiology and Radiotherapy, University Hospital Tor Vergata, Italy Department of Biomedicine and Prevention, Faculty of Medicine, University of Rome Tor Vergata, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionKennedy's disease (KD) is a progressive degenerative disorder affecting lower motor neurons. We investigated the correlation between disease severity and whole brain white matter microstructure, including upper motor neuron tracts, by using diffusion-tensor imaging (DTI) in eight patients with KD in whom disease severity was evaluated using the Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS).

methodsFrom DTI acquisitions we obtained maps of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (L1) and radial diffusivities (L2, L3). We then employed tract-based spatial statistics (TBSS) to investigate within-patient correlations of DTI invariants with ALSFRS and disease duration (DD).

resultsWe found a significant correlation between low ALSFRS and 1) low FA values in association commissural and projection fibers, and 2) high L3 values in commissural tracts and fronto-parietal white matter. Additionally, we found a significant association between longer DD and 1) low FA in the genu and body of corpus callosum, association fibers and midbrain and 2) high L1 in projection and association tracts.

conclusionsThe associations between clinical variables and white matter microstructural changes in areas thought to be spared by the disease process support the hypothesis of a multisystem involvement in the complex pathogenic mechanisms responsible for the clinical disability of these patients.

Indexed as

AdultAgedBrainBulbo-Spinal Atrophy, X-LinkedDiffusion Tensor ImagingFemaleHumansMaleMiddle AgedNerve Fibers, MyelinatedReproducibility of ResultsSensitivity and SpecificityALSFRSdisease durationDTIfractional anisotropyKennedy’s diseasemean diffusivityTBSS

Identifiers

PMID25963157
PMCPMC4757151

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.