ArticleBMC infectious diseases2015
Antimicrobial susceptibility of travel-related Salmonella enterica serovar Typhi isolates detected in Switzerland (2002-2013) and molecular characterization of quinolone resistant isolates.
Article in BMC infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 34 citations in OpenAlex.
- Colonization with extended-spectrum beta-lactamase-producing Escherichia coli and traveler's diarrhea attack rates among travelers to India: a systematic review and meta-analysis.Tropical diseases, travel medicine and vaccines · 2022Review
- Prevalence of Antimicrobial Resistance Genes inTropical medicine and infectious disease · 2022Review
- Review
- Emerging high-level ciprofloxacin-resistant Salmonella enterica serovar typhi haplotype H58 in travelers returning to the Republic of Korea from India.PLoS neglected tropical diseases · 2021Article
- Travel-Related Antimicrobial Resistance: A Systematic Review.Tropical medicine and infectious disease · 2021Review
- Occurrence of plasmid mediated fluoroquinolone resistance genes amongst enteric bacteria isolated from human and animal sources in Delta State, Nigeria.AIMS microbiology · 2021Article
- Antimicrobial Resistance inMicrobiology insights · 2021Article
- Travel-Related Typhoid Fever: Narrative Review of the Scientific Literature.International journal of environmental research and public health · 2020Review
- Transmission of ciprofloxacin resistance inEmerging microbes & infections · 2019Article
- Evolution and transmission of a conjugative plasmid encoding both ciprofloxacin and ceftriaxone resistance in Salmonella.Emerging microbes & infections · 2019Article
- Prevalence and Characterization of Fluoroquinolone ResistantFrontiers in microbiology · 2019Article
- Identification and Characterization of Conjugative Plasmids That Encode Ciprofloxacin Resistance in Salmonella.Antimicrobial agents and chemotherapy · 2018Article
- Travel and the Spread of Drug-Resistant Bacteria.Current infectious disease reports · 2018Review
- Bacterial plasmid-mediated quinolone resistance genes in aquatic environments in China.Scientific reports · 2017Article
- Renaissance of Conventional First-Line Antibiotics inBioMed research international · 2017Article
- Characteristics of bacterial pathogens associated with acute diarrhea in children under 5 years of age: a hospital-based cross-sectional study.BMC infectious diseases · 2016Article
- Typhoidal Salmonellae: Use of Multi-Locus Sequence Typing to Determine Population Structure.PloS one · 2016Article
- SOS response and its regulation on the fluoroquinolone resistance.Annals of translational medicine · 2015Review
- Increasing prevalence of ciprofloxacin-resistant food-borne Salmonella strains harboring multiple PMQR elements but not target gene mutations.Scientific reports · 2015Article
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5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTyphoid fever is an acute, invasive, and potentially fatal systemic infection caused by Salmonella enterica subspecies enterica serotype Typhi (S. Typhi). Drug resistance to antimicrobials such as ciprofloxacin is emerging in developing countries, threatening the efficacy of treatment of patients in endemic regions as well as of travellers returning from these countries.
methodsWe compared the antimicrobial resistance profiles of 192 S. Typhi isolated from patients over a time span of twelve years. Susceptibility testing was done by the disk diffusion method. A representative selection of isolates (n = 41) was screened by PCR for mutations in the quinolone resistance-determining regions (QRDRs) of the gyrA and parC genes and all 192 isolates were screened for plasmid-mediated quinolone resistance (PMQR) genes. Multilocus sequence typing (MLST) was used to investigate the sequence type of isolates from patients with a known history of international travel.
resultsResistance rates for nalidixic acid increased from 20 % to 66.7 % between 2002 and 2013. Resistance to ciprofloxacin was detected in 55.6 % of the isolates by 2013. Ciprofloxacin resistance was predominantly associated with the triple substitutions Ser83 → Phe and Asp87 → Asn in GyrA and Ser80 → Ile in ParC. The plasmid-mediated resistance gene qnrS1 was detected in two isolates. Sequence type ST1 was associated with the Indian subcontinent, while ST2 was distributed internationally. Multidrug resistance was noted for 11.5 % of the isolates.
conclusionsFluoroquinolone resistant S. Typhi constitute a serious public health concern in endemic areas as well as in industrialized countries. Increased surveillance of global patterns of antimicrobial resistance is necessary and the control of resistant strains is of the utmost importance to maintain treatment options.
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