ReviewCardiovascular journal of Africa
Rheumatic heart disease in Africa: is there a role for genetic studies?
Review in Cardiovascular journal of Africa. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Risk Factors of Rheumatic Heart Disease in a Children's Hospital in Khartoum: A Case-Control Study.Cureus · 2024Article
- Cardiac patients' surgery outcome and associated factors in Ethiopia: application of machine learning.BMC pediatrics · 2024Article
- Post-surgery survival and associated factors for cardiac patients in Ethiopia: applications of machine learning, semi-parametric and parametric modelling.BMC medical informatics and decision making · 2024Article
- The prevalence of rheumatic heart disease in Ethiopia: a systematic review and meta-analysis.Tropical diseases, travel medicine and vaccines · 2023Review
- Rheumatic Heart Disease in East Africa: A Systematic Review and Meta-Analysis.International journal of rheumatology · 2023Review
- Pattern of rheumatic heart disease among patients attending at a tertiary care hospital in Somalia: first report from Somalia.American journal of cardiovascular disease · 2023Article
- Using Point-of-Care Ultrasound in Heart Failure Diagnosis and Management in Rural and Resource-Limited Settings.CASE (Philadelphia, Pa.) · 2022Article
- Differences in socio-demographic and risk factor profile, clinical presentation, and outcomes between patients with and without RHD heart failure in Sub-Saharan Africa: results from the THESUS-HF registry.Cardiovascular diagnosis and therapy · 2021Article
- The role of causal knowledge in stigma considerations in African genomics research: Views of South African Xhosa people.Social science & medicine (1982) · 2021Article
- Prevalence of rheumatic heart disease in a major referral cardiology clinic in Ethiopia: A retrospective cross-sectional study.PloS one · 2021Article
- Generating Global Priority for Addressing Rheumatic Heart Disease: A Qualitative Policy Analysis.Journal of the American Heart Association · 2020Review
- Data Resource Profile: Cardiovascular H3Africa Innovation Resource (CHAIR).International journal of epidemiology · 2019Article
- Health Challenges of the Pacific Region: Insights From History, Geography, Social Determinants, Genetics, and the Microbiome.Frontiers in immunology · 2019Review
- Association of ficolin-2 (FCN2) functional polymorphisms and protein levels with rheumatic fever and rheumatic heart disease: relationship with cardiac function.Archives of medical sciences. Atherosclerotic diseases · 2018Article
- Building a Platform to Enable NCD Research to Address Population Health in Africa: CVD Working Group Discussion at the Sixth H3Africa Consortium Meeting in Zambia.Global heart · 2016Article
- Cardiovascular magnetic resonance imaging in rheumatic heart disease.Cardiovascular journal of AfricaArticle
- First Malian series of surgery for rheumatic valve disease: opening of the centre, clinical features and peri-operative realities.Cardiovascular journal of AfricaArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rheumatic heart disease (RHD) constitutes a leading cause of premature death and incapacity in Africa, where it is encountered in younger people, and shows a much faster and more malignant course than that seen in Europe or North America. While it is well established that RHD is a consequence of recurrent, untreated group A β-haemolytic streptococcal infections (GAS), the pathogenesis is incompletely understood, and the variation in natural history and phenotypes are not fully explained. In Africa patients are rarely diagnosed with acute rheumatic fever (ARF). They usually present in the late stages of RHD, with the severe and virulent forms occurring at early ages, therefore leading to high morbidity and mortality in young patients. Evidence suggests that genetic factors may be involved in determining susceptibility to ARF as well as the severity and outcomes of RHD. However, the results of genetic studies have been inconsistent, and conflicting results have been found in series from Africa when compared to other parts of the globe. Genetic studies in the African context are therefore justified to understand the genomic and epigenetic drivers of heterogeneity in individual responses to GAS infections and progression to RHD. Platforms such as the global registry of RHD represent an opportunity for adequately powered genome-wide association studies. The discovery of all genetic susceptibility loci through whole-genome scanning may provide a clinically useful genetic risk-prediction tool that will potentially allow echocardiographic screening and secondary prophylaxis for moderate lesions to be directed to those at higher risk, therefore reducing the burden of the disease to the health system, the work health force and the communities of this resource-strained continent.
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