Evidence map›Paper›PMID 25962885›Full record

Trial reportTrials2015

Successful knowledge translation intervention in long-term care: final results from the vitamin D and osteoporosis study (ViDOS) pilot cluster randomized controlled trial.

Courtney C Kennedy, George Ioannidis, Lehana Thabane, Jonathan D Adachi, Sharon Marr, Lora M Giangregorio, Suzanne N Morin, Richard G Crilly, Robert G Josse, Lynne Lohfeld and 9 more

Registry-linked trialAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Trials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01398527 (An Interdisciplinary Knowledge Translation Intervention in Long-term Care), which is not on this map. Cited by 40 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01398527 nacompletednot on this map

An Interdisciplinary Knowledge Translation Intervention in Long-term Care: The Vitamin D and Osteoporosis Study (ViDOS) Pilot Cluster Randomized Controlled Trial

TypeinterventionalSponsorMcMaster UniversityRan2009 to 2013Enrolled40ConditionsOsteoporosisArmsEduc sessions & LTC Osteoporosis toolkit
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 14 syntheses or guidelines pooled it.

  1. Pooled it
  2. Application of the Knowledge-to-Action framework in translating nutrition and dietetic knowledge into practice: A systematic review.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2025
    Pooled it
  3. Interventions for preventing falls in older people in care facilities.The Cochrane database of systematic reviews · 2025
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  4. Audit and feedback: effects on professional practice.The Cochrane database of systematic reviews · 2025
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  14. How Can We Improve Osteoporosis Care? A Systematic Review and Meta-Analysis of the Efficacy of Quality Improvement Strategies for Osteoporosis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Courtney C KennedyMcMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada. kennedyc@hhsc.ca.
George IoannidisMcMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada. g.ioannidis@sympatico.ca.
Lehana ThabaneMcMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada. thabanl@mcmaster.ca.
Jonathan D AdachiMcMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada. adachi@sympatico.ca.
Sharon MarrMcMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada. marrs@mcmaster.ca.
Lora M GiangregorioUniversity of Waterloo, 200 University Avenue West, Waterloo, ON, N2L 3G1, Canada. lmgiangr@uwaterloo.ca.
Suzanne N MorinMcGill University, 845Sherbrooke Street West, Montreal, QC, H3A 0G4, Canada. suzanne.morin@mcgill.ca.
Richard G CrillyWestern University, Parkwood Hospital, 801 Commissioners Road East, London, ON, N6C 5 J1, Canada. crilly@sjhc.london.on.ca.
Robert G JosseUniversity of Toronto, St. Michael's Hospital, 30 Bond Street, Toronto, ON, M5B 1 W8, Canada. josser@smh.toronto.on.ca.
Lynne LohfeldMcMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada. lohfeld@mcmaster.ca.
Laura E PickardMcMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada. pickardl@hhsc.ca.
Mary-Lou van der HorstMcMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada. dhm9@xplornet.com.
Glenda CampbellMcMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada. ecampbell49@quickclic.net.
Jackie StroudMedical Pharmacies Group Limited, 590 Granite Crt, Pickering, ON, L1W 3X6, Canada. jstroud@medicalpharmacies.com.
Lisa DolovichMcMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada. ldolovic@mcmaster.ca.
Anna M SawkaUniversity of Toronto, St. Michael's Hospital, 30 Bond Street, Toronto, ON, M5B 1 W8, Canada. sawka@uhn.on.ca.
Ravi JainOsteoporosis Canada, Suite 301, 1090 Don Mills Road, Toronto, ON, M3C 3R6, Canada. RJain@osteoporosis.ca.
Lynn NashMcMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada. nashl@mcmaster.ca.
Alexandra PapaioannouMcMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada. papaioannou@hhsc.ca.

Funding

CIHR 114982-1CIHR MOP-114982
6 · The paper itself

Abstract

backgroundFew studies have systematically examined whether knowledge translation (KT) strategies can be successfully implemented within the long-term care (LTC) setting. In this study, we examined the effectiveness of a multifaceted, interdisciplinary KT intervention for improving the prescribing of vitamin D, calcium and osteoporosis medications over 12-months.

methodsWe conducted a pilot, cluster randomized controlled trial in 40 LTC homes (21 control; 19 intervention) in Ontario, Canada. LTC homes were eligible if they had more than one prescribing physician and received services from a large pharmacy provider. Participants were interdisciplinary care teams (physicians, nurses, consultant pharmacists, and other staff) who met quarterly. Intervention homes participated in three educational meetings over 12 months, including a standardized presentation led by expert opinion leaders, action planning for quality improvement, and audit and feedback review. Control homes did not receive any additional intervention. Resident-level prescribing and clinical outcomes were collected from the pharmacy database; data collectors and analysts were blinded. In addition to feasibility measures, study outcomes were the proportion of residents taking vitamin D (≥800 IU/daily; primary), calcium ≥500 mg/day and osteoporosis medications (high-risk residents) over 12 months. Data were analyzed using the generalized estimating equations technique accounting for clustering within the LTC homes.

resultsAt baseline, 5,478 residents, mean age 84.4 (standard deviation (SD) 10.9), 71% female, resided in 40 LTC homes, mean size = 137 beds (SD 76.7). In the intention-to-treat analysis (21 control; 19 intervention clusters), the intervention resulted in a significantly greater increase in prescribing from baseline to 12 months between intervention versus control arms for vitamin D (odds ratio (OR) 1.82, 95% confidence interval (CI): 1.12, 2.96) and calcium (OR 1.33, 95% CI: 1.01, 1.74), but not for osteoporosis medications (OR 1.17, 95% CI: 0.91, 1.51). In secondary analyses, excluding seven nonparticipating intervention homes, ORs were 3.06 (95% CI: 2.18, 4.29), 1.57 (95% CI: 1.12, 2.21), 1.20 (95% CI: 0.90, 1.60) for vitamin D, calcium and osteoporosis medications, respectively.

conclusionsOur KT intervention significantly improved the prescribing of vitamin D and calcium and is a model that could potentially be applied to other areas requiring quality improvement.

trial registrationClinicalTrials.gov: NCT01398527 . Registered: 19 July 2011.

Indexed as

Dietary SupplementsLong-Term CarePractice Patterns, Physicians'Accidental FallsAgedAged, 80 and overBone Density Conservation AgentsCalciumCooperative BehaviorDrug PrescriptionsEducation, Medical, ContinuingEducation, Nursing, ContinuingFemaleHomes for the AgedHumansInservice TrainingBone Density Conservation AgentsCalciumVitamin D

Identifiers

PMID25962885
PMCPMC4431601

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.