ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2015
Preeclampsia is Characterized by Fetal NK Cell Activation and a Reduction in Regulatory T Cells.
Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Single-Cell Analysis of Preeclamptic Cord Blood Mononuclear Cells Revealed Activation of Heme-Associated Signalling Pathways.Journal of cellular and molecular medicine · 2026Article
- Shaping immunity: the influence of the maternal gut bacteria on fetal immune development.Seminars in immunopathology · 2025Review
- A comprehensive review of the roles of T-cell immunity in preeclampsia.Frontiers in immunology · 2025Review
- Antiretroviral Therapy at Conception Leads to Lower Peripheral CD49aJournal of immunology research · 2025Article
- Bioinformatic Analysis of Apoptosis-Related Genes in Preeclampsia Using Public Transcriptomic and Single-Cell RNA Sequencing Datasets.Journal of inflammation research · 2025Article
- TGFβ signalling: a nexus between inflammation, placental health and preeclampsia throughout pregnancy.Human reproduction update · 2024Review
- Pregnancy induced hypertension and umbilical cord blood DNA methylation in newborns: an epigenome-wide DNA methylation study.BMC pregnancy and childbirth · 2024Article
- The central role of natural killer cells in preeclampsia.Frontiers in immunology · 2023Review
- Successful pregnancies in post-kidney transplant couples: four case reports.Frontiers in immunology · 2023Article
- Association between preeclampsia and HIV: a case-control study in urban South Africa.AJOG global reports · 2022Article
- Clinical outcomes of hypertensive disorders in pregnancy in the offspring during perinatal period, childhood, and adolescence.Journal of human hypertension · 2021Review
- Biology and pathology of the uterine microenvironment and its natural killer cells.Cellular & molecular immunology · 2021Review
- Taming the Sentinels: Microbiome-Derived Metabolites and Polarization of T Cells.International journal of molecular sciences · 2020Review
- Regulatory T Cells Play a Role in a Subset of Idiopathic Preterm Labor/Birth and Adverse Neonatal Outcomes.Cell reports · 2020Article
- HLA-G Polymorphisms Associated with HIV Infection and Preeclampsia in South Africans of African Ancestry.BioMed research international · 2020Article
- Morphometric image analysis of placental C-type lectin domain family 2, member D (CLEC2D) immuno-expression in HIV associated pre-eclampsia.European journal of obstetrics & gynecology and reproductive biology: X · 2019Article
- Pre-eclampsia: the role of highly active antiretroviral therapy and immune markers.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019Review
- Placental implantation over prior cesarean scar causes activation of fetal regulatory T cells.Immunity, inflammation and disease · 2018Article
- The T helper type 17/regulatory T cell paradigm in pregnancy.Immunology · 2016Review
- Preeclampsia is Characterized by Fetal NK Cell Activation and a Reduction in Regulatory T Cells.American journal of reproductive immunology (New York, N.Y. : 1989) · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
problemPreeclampsia affects 3-17% of pregnancies worldwide and has serious consequences for both the mother and the fetus. As maternal-fetal immune tolerance is bidirectional, fetal immunopathology may play a significant role in the pathogenesis of pregnancy disorders. Nevertheless, the impact of preeclampsia on the fetal immune system is unclear. METHOD OF STUDY: In this case-control study, we examined the phenotype of innate and adaptive immune cells from the cord blood of 3rd trimester babies born to healthy mothers and compared them to cord blood from 3rd trimester babies born to mothers with symptomatic preeclampsia.
resultsThe ratio of CD56hi CD16- non-activated/regulatory NK cells to CD56lo CD16+ activated/effector NK cells as well as the proportion of CD4+ T cells was significantly decreased in the cord blood of babies born to preeclamptic mothers. The percentage of FoxP3+ Treg, especially the FoxP3lo populations (resting Treg and cytokine Treg), were significantly reduced. Importantly, this reduction in FoxP3+ Treg affected the ratio of CD8+ effector T cells per FoxP3+ Treg in the cord blood of babies born to preeclamptic mothers.
conclusionThese observations indicate that there are significant fetal immune system derangements during preeclampsia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.