ArticleThe American journal of tropical medicine and hygiene2015
Emergence of a new lineage of Cache Valley virus (Bunyaviridae: Orthobunyavirus) in the Northeastern United States.
Article in The American journal of tropical medicine and hygiene, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Nairobi Sheep Disease Virus: A Historical and Epidemiological Perspective.Frontiers in veterinary science · 2020Pooled it
- Epidemiological investigation of Shuni virus infections in hospitals in two provinces of South Africa (2019-2021) using molecular and serological surveillance.PLoS neglected tropical diseases · 2026Article
- Zoonotic Abortifacient Agents in Bovine Abortion: Diagnostic Assessment of 125 Cases (2015-2017).Veterinary medicine and science · 2025Article
- Public health significance of the white-tailed deer (Odocoileus virginianus) and its role in the eco-epidemiology of tick- and mosquito-borne diseases in North America.Parasites & vectors · 2025Review
- Transfusion-Transmitted Cache Valley Virus Infection in a Kidney Transplant Recipient With Meningoencephalitis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Comparison of Immunogenicity Between a Candidate Live Attenuated Vaccine and an Inactivated Vaccine for Cache Valley Virus.Viral immunology · 2023Article
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- Role of Anopheles Mosquitoes in Cache Valley Virus Lineage Displacement, New York, USA.Emerging infectious diseases · 2022Article
- Monoclonal antibodies to Cache Valley virus for serological diagnosis.PLoS neglected tropical diseases · 2022Article
- Novel murine models for studying Cache Valley virus pathogenesis andEmerging microbes & infections · 2021Article
- Zoonotic and reverse zoonotic transmission of viruses between humans and pigs.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2021Review
- Reassortant Cache Valley Virus Associated With Acute Febrile, Nonneurologic Illness, Missouri.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Vector competence of Virginia mosquitoes for Zika and Cache Valley viruses.Parasites & vectors · 2020Article
- Cache Valley virus: A scoping review of the global evidence.Zoonoses and public health · 2019Article
- Infection and transmission of Cache Valley virus by Aedes albopictus and Aedes aegypti mosquitoes.Parasites & vectors · 2019Article
- Development of reverse genetics systems and investigation of host response antagonism and reassortment potential for Cache Valley and Kairi viruses, two emerging orthobunyaviruses of the Americas.PLoS neglected tropical diseases · 2018Article
- Fatal Cache Valley virus meningoencephalitis associated with rituximab maintenance therapy.American journal of hematology · 2018Review
- Cache Valley Virus in Aedes japonicus japonicus Mosquitoes, Appalachian Region, United States.Emerging infectious diseases · 2018Article
- A Review of Bunyamwera, Batai, and Ngari Viruses: UnderstudiedFrontiers in veterinary science · 2018Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cache Valley virus (CVV; Family Bunyavidae, Genus Orthobunyavirus) is a mosquito-borne zoonosis that frequently infects humans and livestock in North and Central America. In the northeastern United States, CVV transmission is unpredictable from year-to-year and may derive from the periodic extinction and reintroduction of new virus strains into this region. To evaluate this possibility, we sequenced and analyzed numerous CVV isolates sampled in Connecticut during an 18-year period to determine how the virus population may change over time. Phylogenetic analyses showed the establishment of a new viral lineage during 2010 that became dominant by 2014 and appears to have originated from southern Mexico. CVV strains from Connecticut also grouped into numerous sub-clades within each lineage that included viruses from other U.S. states and Canada. We did not observe the development and stable persistence of local viral clades in Connecticut, which may reflect the episodic pattern of CVV transmission. Together, our data support the emergence of a new lineage of CVV in the northeastern United States and suggest extensive dispersal of viral strains in North America.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.