ArticleThe American journal of tropical medicine and hygiene2015
Temperature and the field stability of a dengue rapid diagnostic test in the tropics.
Article in The American journal of tropical medicine and hygiene, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Evolutionary Dynamics-AwareACS omega · 2026Article
- Accuracy and Usability of a New Rapid Diagnostic Test for the Diagnosis of Dengue in Vientiane, Laos.Open forum infectious diseases · 2026Article
- Cost-effectiveness analysis of a multiplex lateral flow rapid diagnostic test for acute non-malarial febrile illness in rural Cambodia and Bangladesh.The Lancet regional health. Southeast Asia · 2024Article
- Dengue 1 outbreak in Rosso, northern Senegal, October 2021: entomologic investigations.Journal of medical entomology · 2024Article
- Harnessing Dengue Rapid Diagnostic Tests for the Combined Surveillance of Dengue, Zika, and Chikungunya Viruses in Laos.The American journal of tropical medicine and hygiene · 2020Article
- Article
- A review of dengue diagnostics and implications for surveillance and control.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2019Review
- Rapid Diagnostic Tests as a Source of Dengue Virus RNA for Envelope Gene Amplification: A Proof of Concept.The American journal of tropical medicine and hygiene · 2019Article
- Comparison of two rapid diagnostic tests during a large dengue virus serotype 3 outbreak in the Solomon Islands in 2013.PloS one · 2018Article
- Molecular epidemiology of dengue viruses in three provinces of Lao PDR, 2006-2010.PLoS neglected tropical diseases · 2018Article
- Temperature of a Dengue Rapid Diagnostic Test under Tropical Climatic Conditions: A Follow Up Study.PloS one · 2017Article
- Using Rapid Diagnostic Tests as a Source of Viral RNA for Dengue Serotyping by RT-PCR - A Novel Epidemiological Tool.PLoS neglected tropical diseases · 2016Article
- [Diagnosis and treatment of emerging viral diseases : how can we do better ?]Bulletin de l'Academie nationale de medecineArticle
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 4 countries.
Funding
Abstract
The global incidence of dengue has increased significantly in recent decades, resulting in a large public health burden in tropical and subtropical countries. Dengue rapid diagnostic tests (RDTs) can provide accurate, rapid accessible diagnosis for patient management and may be easily used by health workers in rural areas. However, in dengue-endemic areas, ambient temperatures are often higher than manufacturer's recommendation. We therefore evaluated the effect of high temperature over time on the performance of one commonly used dengue RDT, the Standard Diagnostics Bioline Dengue Duo. RDTs were kept in five different conditions (at 4°C, 35°C, 45°C, 60°C, and at fluctuant ambient temperatures in a free-standing hut) for between 2 days and 2 years in the Lao People's Democratic Republic (PDR). RDTs were tested with four control sera (negative, dengue nonstructural protein 1 [NS1], anti-dengue immunoglobulin [Ig] M, and anti-dengue IgG positive). The RDTs had 100% consistency over the 2-year study, despite high temperatures, including in the hut in which temperatures exceeded the manufacturer's recommendations for 29% of time points. These data suggest that the diagnostic accuracy of the SD Bioline Dengue Duo RDT remains stable even after long-term storage at high temperatures. Therefore, use at such ambient temperatures in tropical areas should not jeopardize the dengue diagnostic outcome.
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