ArticleThe American journal of tropical medicine and hygiene2015
Detection of mixed-species infections of Plasmodium falciparum and Plasmodium vivax by nested PCR and rapid diagnostic tests in southeastern Iran.
Article in The American journal of tropical medicine and hygiene, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Rapid diagnostic tests for Plasmodium vivax malaria in endemic countries.The Cochrane database of systematic reviews · 2020Pooled it
- Summary of discordant results between rapid diagnosis tests, microscopy, and polymerase chain reaction for detecting Plasmodium mixed infection: a systematic review and meta-analysis.Scientific reports · 2020Pooled it
- Malaria Slide Bank to Strengthen and Improve the Quality of Malaria Diagnosis: A National Slide Repository in India.The American journal of tropical medicine and hygiene · 2024Article
- Genetic diversity of merozoite surface protein-5 (MSP-5) of Plasmodium vivax isolates from Malaria patients in Iran.BMC infectious diseases · 2023Article
- Article
- Difference between Microscopic and PCR Examination Result for Malaria Diagnosis and Treatment Evaluation in Sumba Barat Daya, Indonesia.Tropical medicine and infectious disease · 2022Article
- A systematic review and meta-analysis on sub-microscopicThe Lancet regional health. Southeast Asia · 2022Article
- A direct, sensitive and high-throughput genus and species-specific molecular assay for large-scale malaria screening.Infectious diseases of poverty · 2022Article
- Key plasma microRNAs variations in patients withHeliyon · 2022Article
- Evaluating performance of multiplex real time PCR for the diagnosis of malaria at elimination targeted low transmission settings of Ethiopia.Malaria journal · 2022Article
- Diagnostic Methods for Non-Falciparum Malaria.Frontiers in cellular and infection microbiology · 2021Review
- Fever in the Returned Pediatric Traveler.Global pediatric health · 2021Review
- Molecular epidemiology of malaria parasite amongst patients in a displaced people's camp in Sudan.Tropical medicine and health · 2020Article
- Malaria situation in Iran: 2002-2017.Malaria journal · 2019Article
- Ribosomal and non-ribosomal PCR targets for the detection of low-density and mixed malaria infections.Malaria journal · 2019Article
- Field evaluation of malaria malachite green loop-mediated isothermal amplification in health posts in Roraima state, Brazil.Malaria journal · 2019Article
- Molecular identification of Plasmodium species responsible for malaria reveals Plasmodium vivax isolates in Duffy negative individuals from southwestern Nigeria.Malaria journal · 2018Article
- An Update on Malaria Rapid Diagnostic Tests.Current infectious disease reports · 2018Review
- Genetic evidence that the Makira region in northeastern Madagascar is a hotspot of malaria transmission.Malaria journal · 2016Article
- Frequency and distribution of mixed Plasmodium falciparum-vivax infections in French Guiana between 2000 and 2008.Malaria journal · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coexistence of two species of Plasmodium in a single host has disrupted the diagnosis and treatment of malaria. This study was designed to evaluate the ability of rapid diagnostic test (RDT) kits for the diagnosis of mixed-species malaria infections in southeastern Iran. A total of 100 malaria patients were included in the study out of 164 randomly suspected symptomatic malaria patients from May to November 2012. Nested polymerase chain reaction (PCR) was also used to judge the ability of microscopy versus RDT kits for detecting mixed species. The sensitivity of light microscopy for the detection of mixed-species malaria infections was 16.6% (95% confidence interval [CI] = 3-49.1). Nested PCR revealed 12 patients with mixed-species infection. The CareStart Pv/Pf Combo kit detected 58% of the mixed-species infections, which were determined by nested PCR (sensitivity = 58.3%; 95% CI = 28.5-83.5). For identifying P. falciparum, P. vivax, and mixed-species infections, the concordance rates (kappa statistics) of microscopy and CareStart Pv/Pf Combo kit with nested PCR were 0.76 and 0.79, respectively (P = 0.001). This study underlines the effectiveness of RDT kits to improve the differentiation of mixed-species malaria infections in endemic areas where the prevalence of chloroquine resistance is high.
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