ArticleMolecular plant pathology2016
Tomato plant cell death induced by inhibition of HSP90 is alleviated by Tomato yellow leaf curl virus infection.
Article in Molecular plant pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 49 citations in OpenAlex.
- The Molecular Cochaperone NbSGT1 May Function as an Endogenous Suppressor of RNA Silencing That Is Recruited by a Potyvirus in Infection of Plants.Molecular plant pathology · 2026Article
- Cleavage of Bcl-2-associated athanogene by metacaspase determines plant antiviral immunity.Nature communications · 2025Article
- Geminiviruses and Food Security: A Molecular Genetics Perspective for Sustainable Agriculture in Africa.Plants (Basel, Switzerland) · 2024Review
- A transition from enemies to allies: how viruses improve drought resilience in plants.Stress biology · 2024Review
- Unveiling the dynamic relationship of viruses and/or symbiotic bacteria with plant resilience in abiotic stress.Stress biology · 2024Review
- Article
- Exploiting Virus Infection to Protect Plants from Abiotic Stresses: Tomato Protection by a Begomovirus.Plants (Basel, Switzerland) · 2022Review
- Seed Protection ofMicroorganisms · 2022Article
- Interplay between abiotic (drought) and biotic (virus) stresses in tomato plants.Molecular plant pathology · 2022Article
- Genome Structures and Evolution Analysis ofFrontiers in plant science · 2022Article
- Article
- Proteome Mapping of South African Cassava Mosaic Virus-Infected Susceptible and Tolerant Landraces of Cassava.Proteomes · 2021Article
- Fungal F8-Culture Filtrate Induces Tomato Resistance against Tomato Yellow Leaf Curl Thailand Virus.Viruses · 2021Article
- Geminivirus-Host Interactions: Action and Reaction in Receptor-Mediated Antiviral Immunity.Viruses · 2021Review
- Geminiviral Triggers and Suppressors of Plant Antiviral Immunity.Microorganisms · 2021Review
- Transcriptome divergence between developmental senescence and premature senescence in Nicotiana tabacum L.Scientific reports · 2020Article
- The Spread and Transmission of Sweet Potato Virus Disease (SPVD) and Its Effect on the Gene Expression Profile in Sweet Potato.Plants (Basel, Switzerland) · 2020Article
- Molecular insight into cotton leaf curl geminivirus disease resistance in cultivated cotton (Gossypium hirsutum).Plant biotechnology journal · 2020Article
- Triticum aestivum heat shock protein 23.6 interacts with the coat protein of wheat yellow mosaic virus.Virus genes · 2019Article
- Plant Antiviral Immunity Against Geminiviruses and Viral Counter-Defense for Survival.Frontiers in microbiology · 2019Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To ensure a successful long-term infection cycle, begomoviruses must restrain their destructive effect on host cells and prevent drastic plant responses, at least in the early stages of infection. The monopartite begomovirus Tomato yellow leaf curl virus (TYLCV) does not induce a hypersensitive response and cell death on whitefly-mediated infection of virus-susceptible tomato plants until diseased tomatoes become senescent. The way in which begomoviruses evade plant defences and interfere with cell death pathways is still poorly understood. We show that the chaperone HSP90 (heat shock protein 90) and its co-chaperone SGT1 (suppressor of the G2 allele of Skp1) are involved in the establishment of TYLCV infection. Inactivation of HSP90, as well as silencing of the Hsp90 and Sgt1 genes, leads to the accumulation of damaged ubiquitinated proteins and to a cell death phenotype. These effects are relieved under TYLCV infection. HSP90-dependent inactivation of 26S proteasome degradation and the transcriptional activation of the heat shock transcription factors HsfA2 and HsfB1 and of the downstream genes Hsp17 and Apx1/2 are suppressed in TYLCV-infected tomatoes. Following suppression of the plant stress response, TYLCV can replicate and accumulate in a permissive environment.
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