ReviewClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2015
The immunoregulatory and fibrotic roles of activin A in allergic asthma.
Review in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Exacerbation of pulmonary fibrosis following acute lung injury via activin-A production by recruited alveolar macrophages.Journal of thoracic disease · 2024Article
- INHBA(+) cancer-associated fibroblasts generate an immunosuppressive tumor microenvironment in ovarian cancer.NPJ precision oncology · 2024Article
- Asthma, allergy and vitamin E: Current and future perspectives.Free radical biology & medicine · 2022Article
- Article
- Activin A Promotes Regulatory T-cell-Mediated Immunosuppression in Irradiated Breast Cancer.Cancer immunology research · 2021Article
- Overexpression of CD36 in mammary fibroblasts suppresses colony growth in breast cancer cell lines.Biochemical and biophysical research communications · 2020Article
- SMAD Signaling Restricts Mucous Cell Differentiation in Human Airway Epithelium.American journal of respiratory cell and molecular biology · 2019Article
- Diagnostic and prognostic values of serum activin-a levels in patients with acute respiratory distress syndrome.BMC pulmonary medicine · 2019Article
- Reevaluation of Pluripotent Cytokine TGF-β3 in Immunity.International journal of molecular sciences · 2018Review
- Deficient Follistatin-like 3 Secretion by Asthmatic Airway Epithelium Impairs Fibroblast Regulation and Fibroblast-to-Myofibroblast Transition.American journal of respiratory cell and molecular biology · 2018Article
- MicroRNA-21 Mediates the Protective Effects of Mesenchymal Stem Cells Derived from iPSCs to Human Bronchial Epithelial Cell Injury Under Hypoxia.Cell transplantation · 2018Article
- Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T cells that restrain asthmatic responses.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Soluble activin type IIB receptor improves fracture healing in a closed tibial fracture mouse model.PloS one · 2017Article
- Immunoregulation by members of the TGFβ superfamily.Nature reviews. Immunology · 2016Review
- Human eosinophil activin A synthesis and mRNA stabilization are induced by the combination of IL-3 plus TNF.Immunology and cell biology · 2016Article
- Imbalance of Amniotic Fluid Activin-A and Follistatin in Intraamniotic Infection, Inflammation, and Preterm Birth.The Journal of clinical endocrinology and metabolism · 2016Article
- MicroRNAs Involved in Asthma After Mesenchymal Stem Cells Treatment.Stem cells and development · 2016Article
- γ-Tocopherol supplementation of allergic female mice augments development of CD11c+CD11b+ dendritic cells in utero and allergic inflammation in neonates.American journal of physiology. Lung cellular and molecular physiology · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activin A, a member of the TGF-β superfamily of cytokines, was originally identified as an inducer of follicle stimulating hormone release, but has since been ascribed roles in normal physiological processes, as an immunoregulatory cytokine and as a driver of fibrosis. In the last 10-15 years, it has also become abundantly clear that activin A plays an important role in the regulation of asthmatic inflammation and airway remodelling. This review provides a brief introduction to the activin A/TGF-β superfamily, focussing on the regulation of receptors and signalling pathways. We examine the contradictory evidence for generalized pro- vs. anti-inflammatory effects of activin A in inflammation, before appraising its role in asthmatic inflammation and airway remodelling specifically by evaluating data from both murine models and clinical studies. We identify key issues to be addressed, paving the way for safe exploitation of modulation of activin A function for treatment of allergic asthma and other inflammatory lung diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.