ArticleEuropean journal of neurology2015
Vitamin D, vitamin D binding protein gene polymorphisms, race and risk of incident stroke: the Atherosclerosis Risk in Communities (ARIC) study.
Article in European journal of neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- A systematic review and meta-analysis of the linkage between low vitamin D and the risk as well as the prognosis of stroke.Brain and behavior · 2024Pooled it
- Vitamin D and Stroke: Effects on Incidence, Severity, and Outcome and the Potential Benefits of Supplementation.Frontiers in neurology · 2020Pooled it
- Lower Vitamin D Status Is Associated with an Increased Risk of Ischemic Stroke: A Systematic Review and Meta-Analysis.Nutrients · 2018Pooled it
- Trial
- Serum Sodium, Potassium, Magnesium, Calcium, and Phosphorus Levels and Risk of Fracture in the Community.The Journal of clinical endocrinology and metabolism · 2025Article
- Review
- Vitamin D binding protein in psychiatric and neurological disorders: Implications for diagnosis and treatment.Genes & diseases · 2024Review
- Vitamin D and Cardiovascular Diseases: From Physiology to Pathophysiology and Outcomes.Biomedicines · 2024Review
- Vitamin D Supplementation in Functional Recovery of Subjects with Severe Acquired Brain Injury: A Pilot Controlled Randomized Study.Neurotrauma reports · 2024Article
- Cardiovascular Impact of Calcium and Vitamin D Supplements: A Narrative Review.Endocrinology and metabolism (Seoul, Korea) · 2023Review
- Vitamin D3 and Ischemic Stroke: A Narrative Review.Antioxidants (Basel, Switzerland) · 2022Review
- Serum 25-hydroxyvitamin D is associated with stroke history in a reverse J-shape.Frontiers in neurology · 2022Article
- Potential role of hypovitaminosis D and vitamin D supplementation during COVID-19 pandemic.QJM : monthly journal of the Association of Physicians · 2021Review
- Does the High Prevalence of Vitamin D Deficiency in African Americans Contribute to Health Disparities?Nutrients · 2021Review
- Determinants of vitamin D activation in patients with acute coronary syndromes and its correlation with inflammatory markers.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2021Article
- Association of Serum 25-Hydroxyvitamin D Concentrations With All-Cause and Cause-Specific Mortality Among Adult Patients With Existing Cardiovascular Disease.Frontiers in nutrition · 2021Article
- Vitamin D serum level in subjects with critical illness polyneuropathy and myopathy.Journal of musculoskeletal & neuronal interactions · 2020Article
- Risk Factors of Vitamin D Deficiency in Chinese Ischemic Stroke Patients: A Cross-Sectional Study.Frontiers in aging neuroscience · 2020Article
- Vitamin D level is associated with severity of coronary artery atherosclerosis and incidence of acute coronary syndromes in non-diabetic cardiac patients.Archives of medical science : AMS · 2019Article
- The impact of homocysteine, BBMC infectious diseases · 2019Observational
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
background and purposeLow vitamin D levels, measured by serum 25-hydroxyvitamin D [25(OH)D], are associated with increased stroke risk. Less is known about whether this association differs by race or D binding protein (DBP) single nucleotide polymorphism (SNP) status. Our objective was to characterize the associations of and interactions between 25(OH)D levels and DBP SNPs with incident stroke. It was hypothesized that associations of low 25(OH)D with stroke risk would be stronger amongst persons with genotypes associated with higher DBP levels.
methods25(OH)D was measured by mass spectroscopy in 12 158 participants in the Atherosclerosis Risk in Communities (ARIC) study (baseline 1990-1992, mean age 57 years, 57% female, 23% black) and they were followed through 2011 for adjudicated stroke events. Two DBP SNPs (rs7041, rs4588) were genotyped. Cox models were adjusted for demographic/behavioral/socioeconomic factors.
resultsDuring a median of 20 years follow-up, 804 incident strokes occurred. The lowest quintile of 25(OH)D (<17.2 ng/ml) was associated with higher stroke risk [hazard ratio (HR) 1.34 (1.06-1.71) versus highest quintile]; this association was similar by race (P interaction 0.60). There was weak evidence of increased risk of stroke amongst those with 25(OH)D < 17.2 ng/ml and either rs7041 TG/GG [HR = 1.29 (1.00-1.67)] versus TT genotype [HR = 1.19 (0.94-1.52)] (P interaction 0.28) or rs4588 CA/AA [HR = 1.37 (1.07-1.74)] versus CC genotype [HR = 1.14 (0.91-1.41)] (P interaction 0.11).
conclusionsLow 25(OH)D is a risk factor for stroke. Persons with low 25(OH)D who are genetically predisposed to high DBP (rs7041 G, rs4588 A alleles), who therefore have lower predicted bioavailable 25(OH)D, may be at greater risk for stroke, although our results were not conclusive and should be interpreted as hypothesis generating.
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