ArticleToxicological sciences : an official journal of the Society of Toxicology2015
Ozone Inhalation Impairs Coronary Artery Dilation via Intracellular Oxidative Stress: Evidence for Serum-Borne Factors as Drivers of Systemic Toxicity.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Effects of Ambient Air Pollution on Blood Pressure Among Children and Adolescents: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2021Pooled it
- Modeling vascular inflammation and atherogenicity after inhalation of ambient levels of ozone: exploratory lessons from transcriptomics.Inhalation toxicology · 2017Pooled it
- A New Mouse Model for Ozone Health Effects Research.Environmental health perspectives · 2026Article
- The impact of environmental pollution and climate change on hypertension: a position paper by the European Society of Hypertension (ESH) Working Group on Environment in Hypertension.Cardiovascular research · 2026Review
- Ozone exposure and cardiovascular disease: A narrative review of epidemiology evidence and underlying mechanisms.Fundamental research · 2025Review
- Association of Gaseous Ambient Air Pollution and Dementia-Related Neuroimaging Markers in the ARIC Cohort, Comparing Exposure Estimation Methods and Confounding by Study Site.Environmental health perspectives · 2024Article
- Noise, Air, and Heavy Metal Pollution as Risk Factors for Endothelial Dysfunction.European cardiology · 2023Review
- Plasma sterols and vitamin D are correlates and predictors of ozone-induced inflammation in the lung: A pilot study.PloS one · 2023Article
- The Association between Air Pollutants Exposure with Pre- and Hypertension by Vitamin C Intakes in Korean Adults: A Cross-Sectional Study from the 2013-2016 Korea National Health and Nutrition Examination.The journal of nutrition, health & aging · 2023Article
- Cigarette smoking and air pollution exposure and their effects on cardiovascular diseases.Frontiers in public health · 2023Review
- Lung-Based, Exosome Inhibition Mediates Systemic Impacts Following Particulate Matter Exposure.Toxics · 2022Article
- Assessment of Kitchen Air Pollution: Health Implications for the Residents of Ilorin South, Nigeria.Journal of environmental and public health · 2022Article
- A self-controlled approach to survival analysis, with application to air pollution and mortality.Environment international · 2021Article
- A Direct Estimate of the Impact of PM2.5, NO2, and O3 Exposure on Life Expectancy Using Propensity Scores.Epidemiology (Cambridge, Mass.) · 2021Article
- Fine particulate matter (PMAmerican journal of physiology. Heart and circulatory physiology · 2021Article
- Ambient air pollution exposure and radiographic pulmonary vascular volumes.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- Early Gestational Exposure to Inhaled Ozone Impairs Maternal Uterine Artery and Cardiac Function.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Impact of COVID-19 on Dentistry.Advances in experimental medicine and biology · 2021Review
- COVID-19 pandemic lockdown: effects on the air quality of South Asia.Environmental sustainability (Singapore) · 2021Article
- Evaluation of oxidative damage and Nrf2 activation by combined pollution exposure in lung epithelial cells.Environmental science and pollution research international · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Ambient ozone (O3) levels are associated with cardiovascular morbidity and mortality, but the underlying pathophysiological mechanisms driving extrapulmonary toxicity remain unclear. This study examined the coronary vascular bed of rats in terms of constrictive and dilatory responses to known agonists following a single O3 inhalation exposure. In addition, serum from exposed rats was used in ex vivo preparations to examine whether bioactivity and toxic effects of inhaled O3 could be conveyed to extrapulmonary systems via the circulation. We found that 24 h following inhalation of 1 ppm O3, isolated coronary vessels exhibited greater basal tone and constricted to a greater degree to serotonin stimulation. Vasodilation to acetylcholine (ACh) was markedly diminished in coronary arteries from O3-exposed rats, compared with filtered air-exposed controls. Dilation to ACh was restored by combined superoxide dismutase and catalase treatment, and also by NADPH oxidase inhibition. When dilute (10%) serum from exposed rats was perfused into the lumen of coronary arteries from unexposed, naïve rats, the O3-induced reduction in vasodilatory response to ACh was partially recapitulated. Furthermore, following O3 inhalation, serum exhibited a nitric oxide scavenging capacity, which may partially explain blunted ACh-mediated vasodilatory responses. Thus, bioactivity from inhalation exposures may be due to compositional changes of the circulation. These studies shed light on possible mechanisms of action that may explain O3-associated cardiac morbidity and mortality in humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.