Evidence map›Paper›PMID 25962336›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2015

Enzyme-Responsive Delivery of Multiple Proteins with Spatiotemporal Control.

Suwei Zhu, Lina Nih, S Thomas Carmichael, Yunfeng Lu, Tatiana Segura

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Review
  2. Review
  3. Brain repair mechanisms after cell therapy for stroke.Brain : a journal of neurology · 2024
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Prolonged release of VEGF and Ang1 from intralesionally implanted hydrogel promotes perilesional vascularization and functional recovery after experimental ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  11. Wearable Bioelectronics for Chronic Wound Management.Advanced functional materials · 2022
    Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Design Challenges in Polymeric Scaffolds for Tissue Engineering.Frontiers in bioengineering and biotechnology · 2021
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Suwei ZhuDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, 420 Westwood Plaza, Los Angeles, CA, 90095, USA.
Lina NihDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, 420 Westwood Plaza, Los Angeles, CA, 90095, USA.
S Thomas CarmichaelDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, 710 Westwood Plaza, Los Angeles, CA, 90095, USA.
Yunfeng LuDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, 420 Westwood Plaza, Los Angeles, CA, 90095, USA.
Tatiana SeguraDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, 420 Westwood Plaza, Los Angeles, CA, 90095, USA.

Funding

VEGF Ligand Presentation and Therapeutic AngiogenesisR01NS079691 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SEGURA, TATIANA · 2012 to 2024
$4.0M
Hydrogels for Local Gene Delivery and Therapeutic AngiogenesisR01HL110592 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SEGURA, TATIANA · 2011 to 2015
$1.8M
HIGH-END CRYOEM INSTRUMENT FOR UCLA ELECTRON IMAGING CTR FOR NANOMACHINES: AIDSS10RR023057 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHOU, Z HONG · 2006 to 2006
$1.6M
NCRR NIH HHS 1S10RR23057NCRR NIH HHS S10 RR023057NHLBI NIH HHS R01 HL110592NHLBI NIH HHS R01HL110592NINDS NIH HHS R01 NS079691NINDS NIH HHS R01NS079691
6 · The paper itself

Abstract

Orchestrated biological materials such as enzymes and growth factors regulate the growth of tissues and organs. A chirality-controlled, single-protein technology is devised to tailor the spatiotemporally defined delivery of therapeutic proteins in response to natural enzymes present at wound sites. Sustained delivery of one protein and sequential delivery of two proteins are demonstrated for stroke and skin wound healing.

Indexed as

NanostructuresAnimalsDermisDiabetes Mellitus, ExperimentalDrug Delivery SystemsEndothelial CellsEnzymesFibroblastsHumansMice, Inbred BALB CMice, Mutant StrainsProteinsProto-Oncogene Proteins c-sisSkinStrokeVascular Endothelial Growth Factor AEnzymesProteinsProto-Oncogene Proteins c-sisVascular Endothelial Growth Factor AVEGFA protein, humanchiral peptidesenzyme responsiveprotein deliverysequential releasewound healing

Identifiers

PMID25962336
PMCPMC4633528

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.