Evidence map›Paper›PMID 25962164›Full record

ArticlePloS one2015

Reduced regional brain cortical thickness in patients with heart failure.

Rajesh Kumar, Santosh K Yadav, Jose A Palomares, Bumhee Park, Shantanu H Joshi, Jennifer A Ogren, Paul M Macey, Gregg C Fonarow, Ronald M Harper, Mary A Woo

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06326996 (Thiamine Intervention and Cognition in Older Adults Undergoing Coronary Artery Bypass Grafting - A Randomized Clinical Trial.), which is not on this map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06326996 early_phase1recruitingnot on this mapstarted 2024, after this paper: background citation

Thiamine Intervention and Cognition in Older Adults Undergoing Coronary Artery Bypass Grafting - A Randomized Clinical Trial.

TypeinterventionalSponsorUniversity of California, Los AngelesRan2024 to 2026Enrolled52ConditionsCoronary Heart Disease, Coronary Artery Bypass GraftingArmsThiamine, Placebo
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.

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  15. Cognitive Impairment in Acute Heart Failure: Narrative Review.Journal of cardiovascular development and disease · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Rajesh KumarDepartment of Anesthesiology, University of California Los Angeles, Los Angeles, California, United States of America; Department of Radiological Sciences, University of California Los Angeles, Los Angeles, California, United States of America; Department of Bioengineering, University of California Los Angeles, Los Angeles, California, United States of America; The Brain Research Institute, University of California Los Angeles, Los Angeles, California, United States of America.
Santosh K YadavDepartment of Anesthesiology, University of California Los Angeles, Los Angeles, California, United States of America.
Jose A PalomaresDepartment of Anesthesiology, University of California Los Angeles, Los Angeles, California, United States of America.
Bumhee ParkDepartment of Anesthesiology, University of California Los Angeles, Los Angeles, California, United States of America.
Shantanu H JoshiDepartment of Neurology, University of California Los Angeles, Los Angeles, California, United States of America.
Jennifer A OgrenSchool of Nursing, University of California Los Angeles, Los Angeles, California, United States of America.
Paul M MaceySchool of Nursing, University of California Los Angeles, Los Angeles, California, United States of America.
Gregg C FonarowDivision of Cardiology, University of California Los Angeles, Los Angeles, California, United States of America.
Ronald M HarperThe Brain Research Institute, University of California Los Angeles, Los Angeles, California, United States of America; Department of Neurobiology, University of California Los Angeles, Los Angeles, California, United States of America.
Mary A WooSchool of Nursing, University of California Los Angeles, Los Angeles, California, United States of America.
University of California, Los Angeles · US

Funding

Blood-Brain Barrier Dysfunction and Brain Injury in Heart FailureR01NR014669 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUMAR, RAJESH, WOO, MARY ANN · 2014 to 2017
$1.9M
Central Autonomic Nervous System Regulation in Heart FailureR01NR013625 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUMAR, RAJESH, WOO, MARY ANN · 2012 to 2015
$1.7M
NINR NIH HHS R01 NR-013625NINR NIH HHS R01 NR013625NINR NIH HHS R01 NR-014669NINR NIH HHS R01 NR014669
6 · The paper itself

Abstract

aimsAutonomic, cognitive, and neuropsychologic deficits appear in heart failure (HF) subjects, and these compromised functions depend on cerebral cortex integrity in addition to that of subcortical and brainstem sites. Impaired autoregulation, low cardiac output, sleep-disordered-breathing, hypertension, and diabetic conditions in HF offer considerable potential to affect cortical areas by loss of neurons and glia, which would be expressed as reduced cortical thicknesses. However, except for gross descriptions of cortical volume loss/injury, regional cortical thickness integrity in HF is unknown. Our goal was to assess regional cortical thicknesses across the brain in HF, compared to control subjects. METHODS AND

resultsWe examined localized cortical thicknesses in 35 HF and 61 control subjects with high-resolution T1-weighted images (3.0-Tesla MRI) using FreeSurfer software, and assessed group differences with analysis-of-covariance (covariates; age, gender; p<0.05; FDR). Significantly-reduced cortical thicknesses appeared in HF over controls in multiple areas, including the frontal, parietal, temporal, and occipital lobes, more markedly on the left side, within areas that control autonomic, cognitive, affective, language, and visual functions.

conclusionHeart failure subjects show reduced regional cortical thicknesses in sites that control autonomic, cognitive, affective, language, and visual functions that are deficient in the condition. The findings suggest chronic tissue alterations, with regional changes reflecting loss of neurons and glia, and presumably are related to earlier-described axonal changes. The pathological mechanisms contributing to reduced cortical thicknesses likely include hypoxia/ischemia, accompanying impaired cerebral perfusion from reduced cardiac output and sleep-disordered-breathing and other comorbidities in HF.

Indexed as

Body Mass IndexBrain Damage, ChronicCase-Control StudiesCerebral CortexCognitionFemaleHeart FailureHumansMagnetic Resonance ImagingMaleMiddle AgedRisk FactorsSleep

Identifiers

PMID25962164
PMCPMC4427362
OpenAlexW363427551

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.