Evidence map›Paper›PMID 25962123›Full record

ArticleNature medicine2015

Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells.

Laura J Pallett, Upkar S Gill, Alberto Quaglia, Linda V Sinclair, Maria Jover-Cobos, Anna Schurich, Kasha P Singh, Niclas Thomas, Abhishek Das, Antony Chen and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 152 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
152citing papers in PubMed, 1 pooled it
13.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

152 citing papers in PubMed, 1 synthesis or guideline pooled it, 269 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Review
  7. T cell adaptation in chronic infections and tumors.Cellular & molecular immunology · 2026
    Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. PD-L1Frontiers in immunology · 2026
    Article
  13. Article
  14. The Immune Microenvironment in Liver Cancer: From Analysis to Targeting.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  15. Tissue-resident memory CD8Nature reviews. Gastroenterology & hepatology · 2025
    Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review

92 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Laura J PallettDivision of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK.
Upkar S GillCentre for Digestive Diseases, Blizard Institute, Bart's and the London School of Medicine and Dentistry, London, UK.
Alberto QuagliaInstitute of Liver Studies, Kings College Hospital, London, UK.
Linda V SinclairDivision of Cell Signaling and Immunology, University of Dundee, Dundee, UK.
Maria Jover-CobosInstitute of Liver and Digestive Health, University College London, London, UK.
Anna SchurichDivision of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK.
Kasha P SinghDivision of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK.ORCID 0000000251999331
Niclas ThomasDivision of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK.
Abhishek DasDivision of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK.
Antony ChenDivision of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK.
Giuseppe FusaiInstitute of Liver and Digestive Health, University College London, London, UK.
Antonio Bertoletti1] Duke-Nus Medical School, Emerging Infectious Disease Program, Singapore. [2] Singapore Institute for Clinical Sciences, Agency of Science and Technology, Singapore.
Doreen A CantrellDivision of Cell Signaling and Immunology, University of Dundee, Dundee, UK.
Patrick T KennedyCentre for Digestive Diseases, Blizard Institute, Bart's and the London School of Medicine and Dentistry, London, UK.
Nathan A DaviesInstitute of Liver and Digestive Health, University College London, London, UK.
Muzlifah Haniffa1] Singapore Institute for Clinical Sciences, Agency of Science and Technology, Singapore. [2] Institute of Cellular Medicine, Newcastle University, UK.
Mala K MainiDivision of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK.
University College London · GBQueen Mary University of London · GBUniversity of Dundee · GBAgency for Science, Technology and Research · SGKing's College Hospital · GBSingapore Institute for Clinical Sciences · SG

Funding

Medical Research Council G0801213Medical Research Council G0901374Medical Research Council MR/M020126/1Wellcome Trust 097418Wellcome Trust 097418/Z/11/ZWellcome Trust 101849Wellcome Trust 101849/Z/13/Z
6 · The paper itself

Abstract

Infection with hepatitis B virus (HBV) results in disparate degrees of tissue injury: the virus can either replicate without pathological consequences or trigger immune-mediated necroinflammatory liver damage. We investigated the potential for myeloid-derived suppressor cells (MDSCs) to suppress T cell-mediated immunopathology in this setting. Granulocytic MDSCs (gMDSCs) expanded transiently in acute resolving HBV, decreasing in frequency prior to peak hepatic injury. In persistent infection, arginase-expressing gMDSCs (and circulating arginase) increased most in disease phases characterized by HBV replication without immunopathology, whilst L-arginine decreased. gMDSCs expressed liver-homing chemokine receptors and accumulated in the liver, their expansion supported by hepatic stellate cells. We provide in vitro and ex vivo evidence that gMDSCs potently inhibited T cells in a partially arginase-dependent manner. L-arginine-deprived T cells upregulated system L amino acid transporters to increase uptake of essential nutrients and attempt metabolic reprogramming. These data demonstrate the capacity of expanded arginase-expressing gMDSCs to regulate liver immunopathology in HBV infection.

Indexed as

AdolescentAdultAntigen PresentationArginaseCD11b AntigenCD8-Positive T-LymphocytesFemaleHepatic Stellate CellsHepatitis BHepatitis B virusHumansLiverMaleMiddle AgedMyeloid CellsArginaseCD11b Antigen

Identifiers

PMID25962123
PMCPMC4458139
OpenAlexW1957522192

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.