ArticleOncogene2016
Rho1-Wnd signaling regulates loss-of-cell polarity-induced cell invasion in Drosophila.
Article in Oncogene, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
- EyaHOST, a modular genetic system for investigation of intercellular and tumor-host interactions in Drosophila melanogaster.Cell reports methods · 2025Article
- Slik maintains tissue homeostasis by preventing JNK-mediated apoptosis.Cell division · 2023Article
- PTP61F Mediates Cell Competition and Mitigates Tumorigenesis.International journal of molecular sciences · 2021Article
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- CtBP modulates Snail-mediated tumor invasion in Drosophila.Cell death discovery · 2021Article
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- Wallenda-Nmo Axis Regulates Growth via Hippo Signaling.Frontiers in cell and developmental biology · 2021Article
- Rox8 promotes microRNA-dependentProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Identification of the Wallenda JNKKK as an Alk suppressor reveals increased competitiveness of Alk-expressing cells.Scientific reports · 2020Article
- A novel regulator of ER CaOncogene · 2020Article
- Two-Faced: Roles of JNK Signalling During Tumourigenesis in theFrontiers in cell and developmental biology · 2020Review
- Multitasking: Dual Leucine Zipper-Bearing Kinases in Neuronal Development and Stress Management.Annual review of cell and developmental biology · 2019Review
- Lic regulates JNK-mediated cell death in Drosophila.Cell proliferation · 2019Article
- Article
- MKK3 modulates JNK-dependent cell migration and invasion.Cell death & disease · 2019Article
- Drosophila Models of Cell Polarity and Cell Competition in Tumourigenesis.Advances in experimental medicine and biology · 2019Review
- Metastasis suppressors: functional pathways.Laboratory investigation; a journal of technical methods and pathology · 2018Review
- Modelling Cooperative Tumorigenesis inBioMed research international · 2018Review
- Article
- Feedback amplification loop drives malignant growth in epithelial tissues.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 2 countries.
Funding
Abstract
Both cell polarity and c-Jun N-terminal kinase (JNK) activity are essential to the maintenance of tissue homeostasis, and disruption of either is commonly seen in cancer progression. Despite the established connection between loss-of-cell polarity and JNK activation, much less is known about the molecular mechanism by which aberrant cell polarity induces JNK-mediated cell migration and tumor invasion. Here we show results from a genetic screen using an in vivo invasion model via knocking down cell polarity gene in Drosophila wing discs, and identify Rho1-Wnd signaling as an important molecular link that mediates loss-of-cell polarity-triggered JNK activation and cell invasion. We show that Wallenda (Wnd), a protein kinase of the mitogen-activated protein kinase kinase kinase family, by forming a complex with the GTPase Rho1, is both necessary and sufficient for Rho1-induced JNK-dependent cell invasion, MMP1 activation and epithelial-mesenchymal transition. Furthermore, Wnd promotes cell proliferation and tissue growth through wingless production when apoptosis is inhibited by p35. Finally, Wnd shows oncogenic cooperation with Ras(V12) to trigger tumor growth in eye discs and causes invasion into the ventral nerve cord. Together, our data not only provides a novel mechanistic insight on how cell polarity loss contributes to cell invasion, but also highlights the value of the Drosophila model system to explore human cancer biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.