Trial reportScientific reports2015
Tissue spray ionization mass spectrometry for rapid recognition of human lung squamous cell carcinoma.
Trial report in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- Rapid discrimination of human oesophageal squamous cell carcinoma by mass spectrometry based on differences in amino acid metabolism.Scientific reports · 2017Trial
- Click-and-Analyze: Automated Pinpoint Ambient Mass Spectrometry with Sheath-Flow Probe Electrospray Ionization.Mass spectrometry (Tokyo, Japan) · 2025Article
- Alterations in lipid profile upon uterine fibroids and its recurrence.Scientific reports · 2021Article
- An investigation to identify tumor microenvironment-related genes of prognostic value in lung squamous cell carcinoma based on The Cancer Genome Atlas.Translational cancer research · 2021Article
- Direct Liquid Extraction and Ionization Techniques for Understanding Multimolecular Environments in Biological Systems (Secondary Publication).Mass spectrometry (Tokyo, Japan) · 2021Article
- Neutral Desorption Extractive Electrospray Ionization Mass Spectrometry Analysis Sputum for Non-Invasive Lung Adenocarcinoma Detection.OncoTargets and therapy · 2021Article
- Validation of Breast Cancer Margins by Tissue Spray Mass Spectrometry.International journal of molecular sciences · 2020Article
- Applications of Mass Spectrometry for Clinical Diagnostics: The Influence of Turnaround Time.Analytical chemistry · 2020Review
- Combination of Low-Temperature Electrosurgical Unit and Extractive Electrospray Ionization Mass Spectrometry for Molecular Profiling and Classification of Tissues.Molecules (Basel, Switzerland) · 2019Article
- Unified representation of high- and low-resolution spectra to facilitate application of mass spectrometric techniques in clinical practice.Clinical mass spectrometry (Del Mar, Calif.) · 2019Article
- Lipids in surgical aerosol as diagnosis biomarkers for discrimination of lung cancer.Cancer management and research · 2019Article
- Investigation Of Small Molecular Substances As Potential Biomarkers For Discrimination Of Gastric Tumor.OncoTargets and therapy · 2019Article
- A Comparison of Tissue Spray and Lipid Extract Direct Injection Electrospray Ionization Mass Spectrometry for the Differentiation of Eutopic and Ectopic Endometrial Tissues.Journal of the American Society for Mass Spectrometry · 2018Article
- Identification of a RNA-Seq based prognostic signature with five lncRNAs for lung squamous cell carcinoma.Oncotarget · 2017Article
- Metabolic Effects of Clenbuterol and Salbutamol on Pork Meat Studied Using Internal Extractive Electrospray Ionization Mass Spectrometry.Scientific reports · 2017Article
- Endometriosis foci differentiation by rapid lipid profiling using tissue spray ionization and high resolution mass spectrometry.Scientific reports · 2017Article
- Direct Analysis and Quantification of Metaldehyde in Water using Reactive Paper Spray Mass Spectrometry.Scientific reports · 2016Article
- Altered phosphatidylcholines expression in sputum for diagnosis of non-small cell lung cancer.Oncotarget · 2016Article
- Lipid and metabolite profiles of human brain tumors by desorption electrospray ionization-MS.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Miniature and Fieldable Mass Spectrometers: Recent Advances.Analytical chemistry · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue spray ionization mass spectrometry (TSI-MS) directly on small tissue samples has been shown to provide highly specific molecular information. In this study, we apply this method to the analysis of 38 pairs of human lung squamous cell carcinoma tissue (cancer) and adjacent normal lung tissue (normal). The main components of pulmonary surfactants, dipalmitoyl phosphatidylcholine (DPPC, m/z 757.47), phosphatidylcholine (POPC, m/z 782.52), oleoyl phosphatidylcholine (DOPC, m/z 808.49), and arachidonic acid stearoyl phosphatidylcholine (SAPC, m/z 832.43), were identified using high-resolution tandem mass spectrometry. Monte Carlo sampling partial least squares linear discriminant analysis (PLS-LDA) was used to distinguish full-mass-range mass spectra of cancer samples from the mass spectra of normal tissues. With 5 principal components and 30-40 Monte Carlo samplings, the accuracy of cancer identification in matched tissue samples reached 94.42%. Classification of a tissue sample required less than 1 min, which is much faster than the analysis of frozen sections. The rapid, in situ diagnosis with minimal sample consumption provided by TSI-MS is advantageous for surgeons. TSI-MS allows them to make more informed decisions during surgery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.