ArticleJournal of abnormal psychology2015
Tobacco withdrawal symptoms mediate motivation to reinstate smoking during abstinence.
Article in Journal of abnormal psychology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Barriers and Facilitators of Adherence to Nicotine Replacement Therapy: A Systematic Review and Analysis Using the Capability, Opportunity, Motivation, and Behaviour (COM-B) Model.International journal of environmental research and public health · 2020Pooled it
- Evaluating the temporal relationships between withdrawal symptoms and smoking relapse.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2019Trial
- Momentary changes in craving predict smoking lapse behavior: a laboratory study.Psychopharmacology · 2018Trial
- Exploring the nature and relationship of tobacco cigarette craving and withdrawal.Journal of psychopathology and clinical science · 2026Article
- Prevalence of cigarette and e-cigarette dual use and associated factors among people who smoke in China aged 20-69 years.BMC public health · 2025Article
- Effects of intranasal oxytocin on cigarette withdrawal and smoking in the laboratory: Differences by sex and social functioning traits.Experimental and clinical psychopharmacology · 2024Article
- Evaluation of Periodontal Clinicoradiographic Status and Whol Salivary Prostaglandin E2 Levels among Users of Water Pipe and Cigarettes.Oral health & preventive dentistry · 2024Article
- Nicotine deprivation amplifies attentional bias toward racial discrimination stimuli in African American adults who smoke cigarettes.Experimental and clinical psychopharmacology · 2023Article
- Identification of candidate genes for nicotine withdrawal in C57BL/6J × DBA/2J recombinant inbred mice.Genes, brain, and behavior · 2023Article
- User Engagement With Mood-Related Content on the National Cancer Institute Smokefree.Gov Initiative Cessation Resources.Health education & behavior : the official publication of the Society for Public Health Education · 2022Article
- Article
- Drug and alcohol dependence acute effects of pod-style e-cigarettes in vaping-naïve smokers.Drug and alcohol dependence · 2021Article
- Anhedonia in tobacco withdrawal among African-American smokers.Experimental and clinical psychopharmacology · 2021Article
- Tobacco Withdrawal Symptoms Before and After Nicotine Deprivation in Veteran Smokers with Posttraumatic Stress Disorder and with Major Depressive Disorder.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2021Article
- Association of frequency of perceived exposure to discrimination with tobacco withdrawal symptoms and smoking lapse behavior in African Americans.Addiction (Abingdon, England) · 2021Article
- Network analysis reveals the associations of past quit experiences on current smoking behavior and motivation to quit.Addictive behaviors · 2021Article
- Relative expected value of drugs versus competing rewards underpins vulnerability to and recovery from addiction.Behavioural brain research · 2020Review
- Addiction is driven by excessive goal-directed drug choice under negative affect: translational critique of habit and compulsion theory.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Review
- Smoking Cessation Attempts and Common Strategies Employed.Deutsches Arzteblatt international · 2020Article
- IRF8 is crucial for the nicotine withdrawal-induced hyperalgesia in mice.Translational neuroscience · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Withdrawal-based theories of addiction hypothesize that motivation to reinstate drug use following acute abstinence is mediated by withdrawal symptoms. Experimental tests of this hypothesis in the tobacco literature are scant and may be subject to methodological limitations. This study utilized a robust within-subject laboratory experimental design to investigate the extent to which composite tobacco withdrawal symptomatology level and 3 unique withdrawal components (i.e., low positive affect, negative affect, and urge to smoke) mediated the effect of smoking abstinence on motivation to reinstate smoking. Smokers (≥10 cigarettes per day; N = 286) attended 2 counterbalanced sessions at which abstinence duration was differentially manipulated (1 hr vs. 17 hr). At both sessions, participants reported current withdrawal symptoms and subsequently completed a task in which they were monetarily rewarded proportional to the length of time they delayed initiating smoking, with shorter latency reflecting stronger motivation to reinstate smoking. Abstinence reduced latency to smoking initiation and positive affect and increased composite withdrawal symptom level, urge, and negative affect. Abstinence-induced reductions in latency to initiating smoking were mediated by each withdrawal component, with stronger effects operating through urge. Combined analyses suggested that urge, negative affect, and low positive affect operate through empirically unique mediational pathways. Secondary analyses suggested similar effects on smoking quantity, few differences among specific urge and affect subtypes, and that dependence amplifies some abstinence effects. This study provides the first experimental evidence that within-person variation in abstinence impacts motivation to reinstate drug use through withdrawal. Urge, negative affect, and low positive affect may reflect unique withdrawal-mediated mechanisms underlying tobacco addiction.
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Registered trials
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