Evidence map›Paper›PMID 25961792›Full record

ArticleNature neuroscience2015

Regulation of axon regeneration by the RNA repair and splicing pathway.

Yuanquan Song, David Sretavan, Ernesto A Salegio, Jim Berg, Xi Huang, Tong Cheng, Xin Xiong, Shan Meltzer, Chun Han, Trong-Tuong Nguyen and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
  2. Insights into the structure and function of the RNA ligase RtcB.Cellular and molecular life sciences : CMLS · 2023
    Review
  3. Article
  4. Review
  5. Article
  6. Regulation of Archease by the mTOR-vATPase axis.Development (Cambridge, England) · 2022
    Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. The microtubule regulatorGenes & development · 2020
    Article
  14. Strategies to Promote Long-Distance Optic Nerve Regeneration.Frontiers in cellular neuroscience · 2020
    Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Intrinsic mechanisms of neuronal axon regeneration.Nature reviews. Neuroscience · 2018
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Yuanquan Song1] Howard Hughes Medical Institute, University of California, San Francisco, California, USA. [2] Department of Physiology, University of California, San Francisco, California, USA.
David SretavanDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California, USA.
Ernesto A SalegioBrain and Spinal Injury Center, University of California, San Francisco, California, USA.
Jim Berg1] Howard Hughes Medical Institute, University of California, San Francisco, California, USA. [2] Department of Physiology, University of California, San Francisco, California, USA.
Xi Huang1] Howard Hughes Medical Institute, University of California, San Francisco, California, USA. [2] Department of Physiology, University of California, San Francisco, California, USA.
Tong Cheng1] Howard Hughes Medical Institute, University of California, San Francisco, California, USA. [2] Department of Physiology, University of California, San Francisco, California, USA.
Xin XiongHoward Hughes Medical Institute, University of California, San Francisco, California, USA.
Shan Meltzer1] Howard Hughes Medical Institute, University of California, San Francisco, California, USA. [2] Department of Physiology, University of California, San Francisco, California, USA.
Chun Han1] Howard Hughes Medical Institute, University of California, San Francisco, California, USA. [2] Department of Physiology, University of California, San Francisco, California, USA.
Trong-Tuong NguyenDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California, USA.
Jacqueline C BresnahanBrain and Spinal Injury Center, University of California, San Francisco, California, USA.
Michael S BeattieBrain and Spinal Injury Center, University of California, San Francisco, California, USA.
Lily Yeh Jan1] Howard Hughes Medical Institute, University of California, San Francisco, California, USA. [2] Department of Physiology, University of California, San Francisco, California, USA.
Yuh Nung Jan1] Howard Hughes Medical Institute, University of California, San Francisco, California, USA. [2] Department of Physiology, University of California, San Francisco, California, USA.
University of California, San Francisco · USHoward Hughes Medical Institute · US

Funding

Rapid-Prototyping and Design CoreP30EY002162 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ULLIAN, ERIK M · 1985 to 2024
$16.8M
Mechanisms of secondary injury after SCIR01NS038079 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BEATTIE, MICHAEL S, BRESNAHAN, JACQUELINE C · 1999 to 2015
$5.8M
MOLECULAR DEVELOPMENT OF CENTRAL RETINAL PATHWAYSR01EY010688 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SRETAVAN, DAVID W · 1994 to 2015
$5.1M
Genetic Dissection of Dendrite DevelopmentR37NS040929 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JAN, YUH NUNG · 2010 to 2016
$2.5M
Mechanistic studies of novel factors regulating axon regeneration in the PNS/CNSK99NS088211 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SONG, YUANQUAN · 2014 to 2015
$190k
Howard Hughes Medical InstituteNEI NIH HHS EY010688-19NEI NIH HHS P30 EY002162NEI NIH HHS R01 EY010688NINDS NIH HHS 1K99NS088211-01NINDS NIH HHS 2R37NS040929NINDS NIH HHS K99 NS088211NINDS NIH HHS R01 NS038079NINDS NIH HHS R37 NS040929
6 · The paper itself

Abstract

Mechanisms governing a neuron's regenerative ability are important but not well understood. We identify Rtca (RNA 3'-terminal phosphate cyclase) as an inhibitor of axon regeneration. Removal of Rtca cell-autonomously enhanced axon regrowth in the Drosophila CNS, whereas its overexpression reduced axon regeneration in the periphery. Rtca along with the RNA ligase Rtcb and its catalyst Archease operate in the RNA repair and splicing pathway important for stress-induced mRNA splicing, including that of Xbp1, a cellular stress sensor. Drosophila Rtca and Archease had opposing effects on Xbp1 splicing, and deficiency of Archease or Xbp1 impeded axon regeneration in Drosophila. Moreover, overexpressing mammalian Rtca in cultured rodent neurons reduced axonal complexity in vitro, whereas reducing its function promoted retinal ganglion cell axon regeneration after optic nerve crush in mice. Our study thus links axon regeneration to cellular stress and RNA metabolism, revealing new potential therapeutic targets for treating nervous system trauma.

Indexed as

AnimalsAxonsCells, CulturedDNA-Binding ProteinsDrosophila ProteinsLigasesMiceNerve CrushNerve RegenerationOptic NerveRetinal Ganglion CellsRNARNA SplicingSciatic NerveDNA-Binding ProteinsDrosophila ProteinsLigasesRNARNA 3'-terminal phosphate cyclaseXbp1 protein, Drosophila

Identifiers

PMID25961792
PMCPMC4446171
OpenAlexW1830711189

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.