Evidence map›Paper›PMID 25961789›Full record

ArticleScientific reports2015

Larynx carcinoma regulates tumor-associated macrophages through PLGF signaling.

Xu Zhou, Ying Qi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Genetically modified mesenchymal stem cells promote spinal fusion through polarized macrophages.Laboratory investigation; a journal of technical methods and pathology · 2022
    Article
  3. Article
  4. PlGF Immunological Impact during Pregnancy.International journal of molecular sciences · 2020
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. YT521 promotes metastases of endometrial cancer by differential splicing of vascular endothelial growth factor A.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Article
  10. Role of miR-138 in the regulation of larynx carcinoma cell metastases.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Article
  11. Article
  12. TIPE2 regulates tumor-associated macrophages in skin squamous cell carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Article
  13. Soluble Flt-1 improves the repair of ankle joint injury in rats.American journal of translational research · 2016
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Xu Zhou1] Otorhinolaryngology Department, Zhongshan Hospital, Fu Dan University, 180 Fenglin Road, Shanghai 200032, China [2] State Key Laboratory of Molecular Engineering of Polymers (Fudan University), 220 Handan Road, Shanghai 200433, China.
Ying QiOtorhinolaryngology Department, Zhongshan Hospital, Fu Dan University, 180 Fenglin Road, Shanghai 200032, China.
Zhongshan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer neovascularization plays an essential role in the metastasis of larynx carcinoma (LC). However, the underlying molecular mechanisms are not completely understood. Recently, we reported that placental growth factor (PLGF) regulates expression of matrix metalloproteinase 3 (MMP3) through ERK/MAPK signaling pathway in LC. Here, we show that MMP9 upregulated in LC, and appeared to be mainly produced by M2 macrophages (tumor-associated macrophages (TAM)). In a transwell co-culture system, PLGF secreted by LC cells triggered macrophage polarization to a TAM subtype that releases MMP9. Moreover, MMP9 was found to be activated in the PLGF-polarized TAM via transforming growth factor β (TGFβ) receptor signaling activation. Furthermore, PLGF in LC cells induced macrophage polarization in vivo, and significantly promoted the growth of LC. Thus, together with our previous work, our study highlights a pivotal role of cross-talk between TAM and LC in regulating the metastasis of LC.

Indexed as

MAP Kinase Signaling SystemAnimalsCell Line, TumorFemaleHumansLaryngeal NeoplasmsMacrophagesMaleMatrix Metalloproteinase 3Matrix Metalloproteinase 9MiceNeoplasm ProteinsPlacenta Growth FactorPregnancy ProteinsTransforming Growth Factor betaMatrix Metalloproteinase 3Matrix Metalloproteinase 9MMP3 protein, humanMmp3 protein, mouseMMP9 protein, humanMmp9 protein, mouseNeoplasm ProteinsPGF protein, humanPgf protein, mousePlacenta Growth FactorPregnancy ProteinsTransforming Growth Factor beta

Identifiers

PMID25961789
PMCPMC4650800
OpenAlexW2254652637

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.