Evidence map›Paper›PMID 25961767›Full record

Trial reportBone marrow transplantation2015

A randomized control trial of a psychosocial intervention for caregivers of allogeneic hematopoietic stem cell transplant patients: effects on distress.

M L Laudenslager, T L Simoneau, K Kilbourn, C Natvig, S Philips, J Spradley, P Benitez, P McSweeney, S K Mikulich-Gilbertson

2 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Bone marrow transplantation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 51 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 5 pooled it
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00833898 phase3completednot on this map

Psychoeducation For BMT Caregivers: Biobehavioral Markers and Outcome

TypeinterventionalSponsorUniversity of Colorado, DenverRan2008 to 2013Enrolled298ConditionsHematopoietic/Lymphoid CancerArmsPaced respiration as part of PEPRR, PEPRR
NCT07116018 nacompletednot on this mapstarted 2025, after this paper: background citation

Feasibility Testing of an Adapted Psychoeducational Intervention for Caregivers of Patients Undergoing Allogeneic Stem Cell Transplant for Hematological Malignancy

TypeinterventionalSponsorUniversity Health Network, TorontoRan2025 to 2026Enrolled17ConditionsCancer, Caregivers, Stem Cell Transplant, PsychoeductionArmsPsychoeducation
3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 5 syntheses or guidelines pooled it, 92 citations in OpenAlex.

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  11. An evidence-based stress management intervention for allogeneic hematopoietic stem cell transplant caregivers: development, feasibility and acceptability.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017
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  14. Nurses' perspectives on caregiver engagement in hematopoietic stem cell transplantation: A qualitative study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

M L LaudenslagerDepartment of Psychiatry, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA.
T L SimoneauDepartment of Psychiatry, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA.
K KilbournDepartment of Psychology, Univerity of Colorado Denver, Denver, CO, USA.
C NatvigDepartment of Psychiatry, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA.
S PhilipsDepartment of Psychiatry, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA.
J Spradley1] Presbyterian/St Luke's Medical Center, Denver, CO, USA [2] Colorado Blood Cancer Institute, Denver, CO, USA.
P BenitezDepartment of Psychiatry, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA.
P McSweeney1] Presbyterian/St Luke's Medical Center, Denver, CO, USA [2] Colorado Blood Cancer Institute, Denver, CO, USA.
S K Mikulich-GilbertsonDepartment of Psychiatry, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA.
University of Colorado Denver · USPresbyterian St. Luke's Medical Center · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Psychoeducation for BMT caregivers: Biobehavioral markers and outcomeR01CA126971 · NCI · UNIVERSITY OF COLORADO DENVER · PI LAUDENSLAGER, MARK L. · 2008 to 2012
$2.7M
NCI NIH HHS 1R01CA126971NCI NIH HHS R01 CA126971
6 · The paper itself

Abstract

Caregivers of patients receiving allogeneic hematopoietic stem cell transplants (allo-HSCT) serve a pivotal role in patient care but experience high stress, anxiety and depression as a result. We theorized that stress management adapted for allo-HSCT caregivers would reduce distress compared with treatment as usual (TAU). Of 267 consecutive caregivers of allo-HSCT patients approached, 148 (mean=53.5 years, 75.7% female) were randomized to either psychosocial intervention (i=74) or TAU (n=74). Eight one-on-one stress management sessions delivered across the 100-day post-transplant period focused on understanding stress, changing role(s) as caregiver, cognitive behavioral stress management, pacing respiration and identifying social support. Primary outcomes included perceived stress (psychological) and salivary cortisol awakening response (CAR) (physiological). Randomized groups were not statistically different at baseline. Mixed models analysis of covariance (intent-to-treat) showed that intervention was associated with significantly lower caregiver stress 3 months post transplant (mean=20.0, 95% confidence interval (95% CI)=17.9-22.0) compared with TAU (mean=23.0, 95% CI=21.0-25.0) with an effect size (ES) of 0.39 (P=0.039). Secondary psychological outcomes, including depression and anxiety, were significantly reduced with ESs of 0.46 and 0.66, respectively. Caregiver CAR did not differ from non-caregiving controls at baseline and was unchanged by intervention. Despite significant caregiving burden, this psychosocial intervention significantly mitigated distress in allo-HSCT caregivers.

Indexed as

CaregiversSocial SupportAdultAgedAged, 80 and overAllograftsFemaleHematopoietic Stem Cell TransplantationHumansMaleMiddle AgedStress, Psychological

Identifiers

PMID25961767
PMCPMC4527944
OpenAlexW330313535

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.