Evidence map›Paper›PMID 25961722›Full record

ArticleOrganic letters2015

Terfestatins B and C, New p-Terphenyl Glycosides Produced by Streptomyces sp. RM-5-8.

Xiachang Wang, Anna R Reynolds, Sherif I Elshahawi, Khaled A Shaaban, Larissa V Ponomareva, Meredith A Saunders, Ibrahim S Elgumati, Yinan Zhang, Gregory C Copley, James C Hower and 6 more

Erratum issuedAbstract read
In one paragraph

Article in Organic letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Bacterial terpenome.Natural product reports · 2021
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
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  19. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Xiachang Wang
Anna R Reynolds
Sherif I Elshahawi
Khaled A Shaaban
Larissa V Ponomareva
Meredith A Saunders
Ibrahim S Elgumati
Yinan Zhang
Gregory C Copley∥Center for Applied Energy Research, University of Kentucky, Lexington, Kentucky 40511, United States.
James C Hower∥Center for Applied Energy Research, University of Kentucky, Lexington, Kentucky 40511, United States.
Manjula Sunkara
Andrew J Morris
Madan K Kharel#School of Pharmacy, University of Maryland Eastern Shore, Princess Anne, Maryland 21853, United States.
Steven G Van Lanen
Mark A Prendergast
Jon S Thorson
University of Kentucky · USUniversity of Maryland Eastern Shore · US

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR000117 · NCATS · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2012 to 2015
$13.3M
Training in Drug Abuse Related Research.T32DA016176 · NIDA · UNIVERSITY OF KENTUCKY · PI DWOSKIN, LINDA P · 2004 to 2020
$4.0M
Thermo/Finnigan TSQ AM Triple Stage Quadrupole Mass SpectrometerS10RR024598 · NCRR · UNIVERSITY OF KENTUCKY · PI MORRIS, ANDREW J · 2008 to 2008
$493k
Advion Triversa Nanomate/ABSciex Nanospray III Ion Source for Targeted LipidomicsS10RR026884 · NCRR · UNIVERSITY OF KENTUCKY · PI MORRIS, ANDREW J · 2011 to 2011
$106k
NCATS NIH HHS UL1 TR000117NCATS NIH HHS UL1TR000117NCRR NIH HHS S10 RR024598NCRR NIH HHS S10 RR026884NIDA NIH HHS T32 DA016176
6 · The paper itself

Abstract

Terfestatins B (1) and C (2), new p-terphenyls bearing a novel unsaturated hexuronic acid (4-deoxy-α-L-threo-hex-4-enopyranuronate), a unique β-D-glycosyl ester of 5-isoprenylindole-3-carboxylate (3) and the same rare sugar, and two new hygromycin precursors, were characterized as metabolites of the coal mine fire isolate Streptomyces sp. RM-5-8. EtOH damage neuroprotection assays using rat hippocampal-derived primary cell cultures with 1, 2, 3 and echoside B (a terfestatin C-3'-β-D-glucuronide from Streptomyces sp. RM-5-8) revealed 1 as potently neuroprotective, highlighting a new potential application of the terfestatin scaffold.

Indexed as

AnimalsGlucosidesGlucuronidesGlycosidesHexuronic AcidsMolecular StructureRatsStreptomycesTerphenyl CompoundsGlucosidesGlucuronidesGlycosidesHexuronic Acidsterfestatin Aterfestatin Bterfestatin CTerphenyl Compounds

Identifiers

PMID25961722
PMCPMC4472964
OpenAlexW337101356

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.