ArticleNature nanotechnology2015
Self-replication of DNA rings.
Article in Nature nanotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- An enzyme-based approach for highly efficient self-replication of DNA origami dimers.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Isothermal assembly of DNA nanostructures.Chemical communications (Cambridge, England) · 2025Review
- Signal amplified colorimetric nucleic acid detection based on autocatalytic hairpin assembly.RSC advances · 2024Article
- Triggered contraction of self-assembled micron-scale DNA nanotube rings.Nature communications · 2024Article
- DNA T-shaped crossover tiles for 2D tessellation and nanoring reconfiguration.Nature communications · 2023Article
- Mutations in artificial self-replicating tiles: A step toward Darwinian evolution.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Proliferating coacervate droplets as the missing link between chemistry and biology in the origins of life.Nature communications · 2021Article
- Probe computing model based on small molecular switch.BMC bioinformatics · 2019Article
- Calculation of π and Classification of Self-avoiding Lattices via DNA Configuration.Scientific reports · 2019Article
- Litters of self-replicating origami cross-tiles.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Fabrication and Characterization of Finite-Size DNA 2D Ring and 3D Buckyball Structures.International journal of molecular sciences · 2018Article
- Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation.Nature chemistry · 2017Review
- Exponential growth and selection in self-replicating materials from DNA origami rafts.Nature materials · 2017Article
- Artificial Molecular Machines.Chemical reviews · 2015Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biology provides numerous examples of self-replicating machines, but artificially engineering such complex systems remains a formidable challenge. In particular, although simple artificial self-replicating systems including wooden blocks, magnetic systems, modular robots and synthetic molecular systems have been devised, such kinematic self-replicators are rare compared with examples of theoretical cellular self-replication. One of the principal reasons for this is the amount of complexity that arises when you try to incorporate self-replication into a physical medium. In this regard, DNA is a prime candidate material for constructing self-replicating systems due to its ability to self-assemble through molecular recognition. Here, we show that DNA T-motifs, which self-assemble into ring structures, can be designed to self-replicate through toehold-mediated strand displacement reactions. The inherent design of these rings allows the population dynamics of the systems to be controlled. We also analyse the replication scheme within a universal framework of self-replication and derive a quantitative metric of the self-replicability of the rings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.