Observational studyScientific reports2015
The Association between Serum Uric Acid Levels and the Prevalence of Vulnerable Atherosclerotic Carotid Plaque: A Cross-sectional Study.
Observational study in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Risk factors for small vessel disease in adults with atherosclerosis: a systematic review and meta-analysis.BMC cardiovascular disorders · 2026Pooled it
- Higher Levels of Lipoprotein Associated Phospholipase A2 is associated with Increased Prevalence of Cognitive Impairment: the APAC Study.Scientific reports · 2016Trial
- The Predictive Value of Atherogenic Index of Plasma for the Presence of Slow Coronary Flow Phenomenon in Patients with Chest Pain and No Obstructive Coronary Arteries: A Single-Center Retrospective Study.International journal of general medicine · 2026Article
- Influence of Uric Acid on Vascular and Cognitive Functions: Evidence for an Ambivalent Relationship.Metabolites · 2024Review
- Endothelial Reprogramming in Atherosclerosis.Bioengineering (Basel, Switzerland) · 2024Review
- Sex, Endothelial Cell Functions, and Peripheral Artery Disease.International journal of molecular sciences · 2023Review
- Serum Urate Levels and Ultrasound Characteristics of Carotid Atherosclerosis across Obesity Phenotypes.Biomedicines · 2023Article
- The Role of Oxidative Stress in Atherosclerosis.Cells · 2022Review
- Investigation of the association between serum uric acid levels and HEART risk score in patients with acute coronary syndrome.Physiological reports · 2022Article
- The number of risk factors increases the recurrence events in ischemic stroke.European journal of medical research · 2022Observational
- Hyperuricemia and Cardiovascular Risk.Cureus · 2021Review
- The Prevalence, Distribution, and Extent of Subclinical Atherosclerosis and Its Relation With Serum Uric Acid in Hypertension Population.Frontiers in cardiovascular medicine · 2021Article
- Serum Uric Acid Levels and Risk of Intracranial Atherosclerotic Stenosis: A Cross-Sectional Study.Neurotoxicity research · 2020Article
- Modifiable risk factors for carotid atherosclerosis: a meta-analysis and systematic review.Annals of translational medicine · 2019Article
- Article
- Carotid artery plaque characterization with a wide-detector computed tomography using a dedicated post-processing 3D analysis: comparison with histology.La Radiologia medica · 2019Article
- Longitudinal association between serum uric acid levels and multiterritorial atherosclerosis.Journal of cellular and molecular medicine · 2019Article
- Evaluation of homocystein and asymmetric dimethyl arginine levels in patients with coronary slow flow phenomenon.Interventional medicine & applied science · 2019Article
- Serum Uric Acid Is Independently Associated with Coronary Calcification in an Asymptomatic Population.Journal of cardiovascular translational research · 2019Article
- Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Little is known about the associations between serum uric acid (SUA) levels and atherosclerotic carotid plaque vulnerability. The aim of this study was to assess the associations of SUA levels with the prevalence of vulnerable atherosclerotic carotid plaque in a community-based cohort. In the Asymptomatic Polyvascular Abnormalities Community (APAC) study, cross-sectional data from 2860 Chinese residents who underwent SUA measurement and ultrasonographic assessment of carotid plaque were analyzed. Multivariable logistic regression models were used to assess the associations of SUA levels with presence of vulnerable carotid plaque. After adjustment for potential confounders, SUA levels were significantly associated with the prevalence of vulnerable plaque amongst the middle-aged adults (odds ratio [OR] = 1.19, 95% confidence interval [CI]: 1.11-1.28). Compared to the lowest quartile, quartiles 2, 3 and 4 had a prevalence OR of 1.33 (1.02-1.74), 1.70 (1.27-2.27) and 2.05 (1.53-2.75), respectively, for the presence of vulnerable carotid plaque (p for trend across quartiles < 0.001). In the APAC study, elevated SUA levels were independently associated with the prevalence of vulnerable carotid plaque in middle-aged adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.