ArticleScientific reports2015
Comprehensive analysis of the T-cell receptor beta chain gene in rhesus monkey by high throughput sequencing.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Subsequent malaria enhances virus-specific T cell immunity in SIV-infected Chinese rhesus macaques.Cell communication and signaling : CCS · 2022Article
- Identification and Tracking of Alloreactive T Cell Clones in Rhesus Macaques Through the RM-scTCR-Seq Platform.Frontiers in immunology · 2021Article
- Partial recovery of disturbed V-J pairing profiles of T-cell receptor in people living with HIV receiving long-term antiretroviral therapy.Science China. Life sciences · 2021Article
- CDR3 sequences in IgA nephropathy are shorter and exhibit reduced diversity.FEBS open bio · 2020Article
- Systematic Profiling of Full-Length Ig and TCR Repertoire Diversity in Rhesus Macaque through Long Read Transcriptome Sequencing.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Altered T cell receptor beta repertoire patterns in pediatric ulcerative colitis.Clinical and experimental immunology · 2019Article
- From Desert to Medicine: A Review of Camel Genomics and Therapeutic Products.Frontiers in genetics · 2019Review
- Profiling of the TCRβ repertoire in non-model species using high-throughput sequencing.Scientific reports · 2018Article
- Article
- T Cell Receptor Alpha Chain Genes in the Teleost Ballan WrasseFrontiers in immunology · 2018Article
- Quantitative analysis and clonal characterization of T-cell receptor β repertoires in patients with advanced non-small cell lung cancer treated with cancer vaccine.Oncology letters · 2017Article
- Article
- T Cell Repertoire Diversity Is Decreased in Type 1 Diabetes Patients.Genomics, proteomics & bioinformatics · 2016Article
- Single-cell TCRseq: paired recovery of entire T-cell alpha and beta chain transcripts in T-cell receptors from single-cell RNAseq.Genome medicine · 2016Article
- Cynomolgus macaque (Macaca fascicularis) immunoglobulin heavy chain locus description.Immunogenetics · 2016Article
- Mathematics in modern immunology.Interface focus · 2016Review
- Comparative Analysis of Immune Repertoires between Bactrian Camel's Conventional and Heavy-Chain Antibodies.PloS one · 2016Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Profiling immune repertoires by high throughput sequencing enhances our understanding of immune system complexity and immune-related diseases in humans. Previously, cloning and Sanger sequencing identified limited numbers of T cell receptor (TCR) nucleotide sequences in rhesus monkeys, thus their full immune repertoire is unknown. We applied multiplex PCR and Illumina high throughput sequencing to study the TCRβ of rhesus monkeys. We identified 1.26 million TCRβ sequences corresponding to 643,570 unique TCRβ sequences and 270,557 unique complementarity-determining region 3 (CDR3) gene sequences. Precise measurements of CDR3 length distribution, CDR3 amino acid distribution, length distribution of N nucleotide of junctional region, and TCRV and TCRJ gene usage preferences were performed. A comprehensive profile of rhesus monkey immune repertoire might aid human infectious disease studies using rhesus monkeys.
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