Trial reportScandinavian journal of primary health care2015
A randomized controlled trial of a diagnostic algorithm for symptoms of uncomplicated cystitis at an out-of-hours service.
Trial report in Scandinavian journal of primary health care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Ibuprofen versus pivmecillinam for uncomplicated urinary tract infection in women-A double-blind, randomized non-inferiority trial.PLoS medicine · 2018Trial
- Considerations for the Adoption of Digital Algorithms and Cardiovascular Decision-Support Tools in Clinical Practice.Critical pathways in cardiology · 2026Review
- Article
- Workload, diagnostic work-up and treatment of urinary tract infections in adults during out-of-hours primary care: a retrospective cohort study.BMC family practice · 2020Observational
- Article
- Pivmecillinam for Uncomplicated Lower Urinary Tract Infections Caused byAntibiotics (Basel, Switzerland) · 2019Article
- Predictors of Symptom Duration and Bacteriuria in Uncomplicated Urinary Tract Infection.Scandinavian journal of primary health care · 2018Article
- Bacteriology in uncomplicated urinary tract infections in Norwegian general practice from 2001-2015.BJGP open · 2018Article
- Factors associated with the duration of symptoms in adult women with suspected cystitis in primary care.PloS one · 2018Article
- Clinical accuracy of point-of-care urine culture in general practice.Scandinavian journal of primary health care · 2017Article
- Urine Culture in Uncomplicated UTI: Interpretation and Significance.Current infectious disease reports · 2016Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare the clinical outcome of patients presenting with symptoms of uncomplicated cystitis who were seen by a doctor, with patients who were given treatment following a diagnostic algorithm.
designRandomized controlled trial.
settingOut-of-hours service, Oslo, Norway.
interventionWomen with typical symptoms of uncomplicated cystitis were included in the trial in the time period September 2010-November 2011. They were randomized into two groups. One group received standard treatment according to the diagnostic algorithm, the other group received treatment after a regular consultation by a doctor. SUBJECTS: Women (n = 441) aged 16-55 years. Mean age in both groups 27 years.
main outcome measuresNumber of days until symptomatic resolution.
resultsNo significant differences were found between the groups in the basic patient demographics, severity of symptoms, or percentage of urine samples with single culture growth. A median of three days until symptomatic resolution was found in both groups. By day four 79% in the algorithm group and 72% in the regular consultation group were free of symptoms (p = 0.09). The number of patients who contacted a doctor again in the follow-up period and received alternative antibiotic treatment was insignificantly higher (p = 0.08) after regular consultation than after treatment according to the diagnostic algorithm. There were no cases of severe pyelonephritis or hospital admissions during the follow-up period.
conclusionUsing a diagnostic algorithm is a safe and efficient method for treating women with symptoms of uncomplicated cystitis at an out-of-hours service. This simplification of treatment strategy can lead to a more rational use of consultation time and a stricter adherence to National Antibiotic Guidelines for a common disorder.
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