Evidence map›Paper›PMID 25961069›Full record

ArticleGenes & diseases2015

Signaling pathways in osteogenesis and osteoclastogenesis: Lessons from cranial sutures and applications to regenerative medicine.

Justin B Maxhimer, James P Bradley, Justine C Lee

Open access · diamondAbstract read
In one paragraph

Article in Genes & diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Justin B MaxhimerDivision of Plastic and Reconstructive Surgery, UCLA David Geffen School of Medicine, CA, USA.
James P BradleyDivision of Plastic and Reconstructive Surgery, Temple University/St. Christopher's Hospital for Children, PA, USA.
Justine C LeeDivision of Plastic and Reconstructive Surgery, UCLA David Geffen School of Medicine, CA, USA ; Division of Plastic and Reconstructive Surgery, Greater Los Angeles VA Healthcare System, USA.
Temple University · USUniversity of California, Los Angeles · USVA Greater Los Angeles Healthcare System · US

Funding

Bone Tissue Engineering Using Mineralized Collagen-GAG ScaffoldsI01BX001367 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI MILLER, TIMOTHY A · 2013 to 2015
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Human Bone Engineering and Resorption in a Novel Mineralized Collagen ScaffoldIK2BX002442 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI LEE, JUSTINE CHIA · 2015 to 2019
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BLRD VA I01 BX001367BLRD VA IK2 BX002442
6 · The paper itself

Abstract

One of the simplest models for examining the interplay between bone formation and resorption is the junction between the cranial bones. Although only roughly a quarter of patients diagnosed with craniosynostosis have been linked to known genetic disturbances, the molecular mechanisms elucidated from these studies have provided basic knowledge of bone homeostasis. This work has translated to methods and advances in bone tissue engineering. In this review, we examine the current knowledge of cranial suture biology derived from human craniosynostosis syndromes and discuss its application to regenerative medicine.

Indexed as

CraniosynostosisOPGOsteoclastOsteogenesisRANKRANKLSignalingTissue engineering

Identifiers

PMID25961069
PMCPMC4425620
OpenAlexW2049902029

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.