Evidence map›Paper›PMID 25960995›Full record

ArticleOcular oncology and pathology2015

Expression of Multidrug Resistance Transporter ABCB5 in a Murine Model of Human Conjunctival Melanoma.

Nadine E de Waard, Paraskevi E Kolovou, Sean P McGuire, Jinfeng Cao, Natasha Y Frank, Markus H Frank, Martine J Jager, Bruce R Ksander

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ocular oncology and pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. The mOncogene · 2022
    Article
  3. Review
  4. Process development and safety evaluation of ABCB5Stem cell research & therapy · 2021
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Nadine E de WaardDepartment of Ophthalmology, Schepens Eye Research Institute and Massachusetts Eye and Ear Infirmary, Boston, Mass., USA ; Department of Ophthalmology, LUMC, Leiden, The Netherlands.
Paraskevi E KolovouDepartment of Ophthalmology, Schepens Eye Research Institute and Massachusetts Eye and Ear Infirmary, Boston, Mass., USA.
Sean P McGuireDepartment of Ophthalmology, Schepens Eye Research Institute and Massachusetts Eye and Ear Infirmary, Boston, Mass., USA.
Jinfeng CaoDepartment of Ophthalmology, LUMC, Leiden, The Netherlands ; Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, China.
Natasha Y FrankDivision of Genetics, Brigham and Women's Hospital, Boston, Mass., USA ; Harvard Stem Cell Institute, Harvard Medical School, Boston, Mass., USA.
Markus H FrankHarvard Stem Cell Institute, Harvard Medical School, Boston, Mass., USA ; Transplant Research Program, Division of Nephrology, Boston Children's Hospital, Boston, Mass., USA.
Martine J JagerDepartment of Ophthalmology, Schepens Eye Research Institute and Massachusetts Eye and Ear Infirmary, Boston, Mass., USA ; Department of Ophthalmology, LUMC, Leiden, The Netherlands.
Bruce R KsanderDepartment of Ophthalmology, Schepens Eye Research Institute and Massachusetts Eye and Ear Infirmary, Boston, Mass., USA.
Massachusetts Eye and Ear Infirmary · USBoston Children's Hospital · USBrigham and Women's Hospital · USSecond Affiliated Hospital of Jilin University · CN

Funding

Immunology of human malignant melanoma initiating cellsR01CA158467 · NCI · BOSTON CHILDREN'S HOSPITAL · PI FRANK, MARKUS H., HODI, FRANK S · 2012 to 2016
$1.9M
Melanoma Stem Cells, Vasculogenesis and Neoplastic ProgressionR01CA138231 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI FRANK, MARKUS H. · 2008 to 2012
$1.7M
ABCB5 P-Glycoprotein in Cancer Multidrug ResistanceR01CA113796 · NCI · BOSTON CHILDREN'S HOSPITAL · PI FRANK, MARKUS H. · 2006 to 2010
$1.5M
Identification and targeting of colon cancer initiating cellsI01BX000516 · VA · VA BOSTON HEALTH CARE SYSTEM · PI FRANK, NATASHA Y · 2011 to 2020
–
ABCB5+ Dermal Stem Cells In Regenerative Wound HealingI01RX000989 · VA · VA BOSTON HEALTH CARE SYSTEM · PI FRANK, NATASHA Y · 2015 to 2017
–
BLRD VA I01 BX000516NCI NIH HHS R01 CA113796NCI NIH HHS R01 CA138231NCI NIH HHS R01 CA158467RRD VA I01 RX000989
6 · The paper itself

Abstract

Conjunctival melanoma (CM) is a rare ocular malignancy with a high tendency to reoccur locally and with a high risk of metastatic disease. Metastases are often unresponsive to conventional treatment. Recently, an animal model was set up using human CM cells. Orthotopic xenografts from human CM were created by subconjunctival injection of three different CM cell lines into NOD.Cg-

Indexed as

ABCB5Conjunctival melanomaStem cells

Identifiers

PMID25960995
PMCPMC4423550
OpenAlexW2102186965

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.