ReviewCurrent environmental health reports2015
The Epigenetic Effects of Prenatal Cadmium Exposure.
Review in Current environmental health reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 85 citations in OpenAlex.
- Endocrine-disrupting properties of heavy metal exposure contribute to the intergenerational effects on learning and memory.Frontiers in endocrinology · 2026Review
- The effects of developmental cadmium exposure on health and disease.Disease models & mechanisms · 2025Review
- Review
- Prenatal exposure to air pollutants and the risk of congenital heart disease: a Korean national health insurance database-based study.Scientific reports · 2024Article
- Mechanisms of Phytoremediation by Resveratrol against Cadmium Toxicity.Antioxidants (Basel, Switzerland) · 2024Review
- Disruption of DNA methylation-mediated cranial neural crest proliferation and differentiation causes orofacial clefts in mice.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The dynamic face of cadmium-induced Carcinogenesis: Mechanisms, emerging trends, and future directions.Current research in toxicology · 2024Review
- Sex-specific transgenerational effects of preconception exposure to arsenite: metabolic phenotypes of C57BL/6 offspring.Archives of toxicology · 2023Article
- Human placental microRNAs dysregulated by cadmium exposure predict neurobehavioral outcomes at birth.Pediatric research · 2023Article
- Does maternal low-dose cadmium exposure increase the risk of offspring to develop metabolic syndrome and/or type 2 diabetes?Life sciences · 2023Review
- The inter- and multi- generational epigenetic alterations induced by maternal cadmium exposure.Frontiers in cell and developmental biology · 2023Review
- Biological Effects of Human Exposure to Environmental Cadmium.Biomolecules · 2022Review
- Umbilical Cord Blood Metal Mixtures and Birth Size in Bangladeshi Children.Environmental health perspectives · 2021Article
- A Systematic Framework for Collecting Site-Specific Sampling and Survey Data to Support Analyses of Health Impacts from Land-Based Pollution in Low- and Middle-Income Countries.International journal of environmental research and public health · 2021Article
- Prenatal methylmercury exposure and DNA methylation in seven-year-old children in the Seychelles Child Development Study.Environment international · 2021Article
- Prenatal Environmental Metal Exposure and Preterm Birth: A Scoping Review.International journal of environmental research and public health · 2021Article
- Gestational Cd Exposure in the CD-1 Mouse Induces Sex-Specific Hepatic Insulin Insensitivity, Obesity, and Metabolic Syndrome in Adult Female Offspring.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Prenatal toxic metal mixture exposure and newborn telomere length: Modification by maternal antioxidant intake.Environmental research · 2020Article
- Implications for prenatal cadmium exposure and adverse health outcomes in adulthood.Toxicology and applied pharmacology · 2020Review
- Lead, Cadmium and Zinc Phytotoxicity Alter DNA Methylation Levels to Confer Heavy Metal Tolerance in Wheat.International journal of molecular sciences · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prenatal exposure to the highly toxic and common pollutant cadmium has been associated with adverse effects on child health and development. However, the underlying biological mechanisms of cadmium toxicity remain partially unsolved. Epigenetic disruption due to early cadmium exposure has gained attention as a plausible mode of action, since epigenetic signatures respond to environmental stimuli and the fetus undergoes drastic epigenomic rearrangements during embryogenesis. In the current review, we provide a critical examination of the literature addressing prenatal cadmium exposure and epigenetic effects in human, animal, and in vitro studies. We conducted a PubMed search and obtained eight recent studies addressing this topic, focusing almost exclusively on DNA methylation. These studies provide evidence that cadmium alters epigenetic signatures in the DNA of the placenta and of the newborns, and some studies indicated marked sexual differences for cadmium-related DNA methylation changes. Associations between early cadmium exposure and DNA methylation might reflect interference with de novo DNA methyltransferases. More studies, especially those including environmentally relevant doses, are needed to confirm the toxicoepigenomic effects of prenatal cadmium exposure and how that relates to the observed health effects of cadmium in childhood and later life.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.