Evidence map›Paper›PMID 25960930›Full record

ArticleOncoimmunology

IFNα signaling through PKC-θ is essential for antitumor NK cell function.

Natalia R Comet, Juan Ignacio Aguiló, Moeez G Rathoré, Elena Catalán, Johan Garaude, Gilles Uzé, Javier Naval, Julián Pardo, Martín Villalba, Alberto Anel

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Natalia R CometApoptosis, Immunity & Cancer Group; Department of Biochemistry and Molecular and Cell Biology ; University of Zaragoza and Aragón Health Research Institute (IIS Aragón) ; Zaragoza, Spain.
Juan Ignacio AguilóApoptosis, Immunity & Cancer Group; Department of Biochemistry and Molecular and Cell Biology ; University of Zaragoza and Aragón Health Research Institute (IIS Aragón) ; Zaragoza, Spain.
Moeez G RathoréINSERM U1040; Université de Montpellier 1; UFR Médecine ; Montpellier, France.
Elena CatalánApoptosis, Immunity & Cancer Group; Department of Biochemistry and Molecular and Cell Biology ; University of Zaragoza and Aragón Health Research Institute (IIS Aragón) ; Zaragoza, Spain.
Johan GaraudeINSERM U1040; Université de Montpellier 1; UFR Médecine ; Montpellier, France.
Gilles UzéCNRS UMR 5235; Université de Montpellier II; Place Eugene Bataillon ; Montpellier, France.
Javier NavalApoptosis, Immunity & Cancer Group; Department of Biochemistry and Molecular and Cell Biology ; University of Zaragoza and Aragón Health Research Institute (IIS Aragón) ; Zaragoza, Spain.
Julián PardoImmune Effector Cells Group; IIS Aragón; Biomedical Research Center of Aragón (CIBA); Nanoscience Institute of Aragon (INA); Zaragoza, Spain ; Aragón I+D Foundation (ARAID) ; Zaragoza, Spain.
Martín VillalbaINSERM U1040; Université de Montpellier 1; UFR Médecine ; Montpellier, France ; Institut de Recherche en Biothérapie (IRB); CHU Montpellier ; Montpellier, France.
Alberto AnelApoptosis, Immunity & Cancer Group; Department of Biochemistry and Molecular and Cell Biology ; University of Zaragoza and Aragón Health Research Institute (IIS Aragón) ; Zaragoza, Spain.
Inserm · FRInstituto de Investigación Sanitaria Aragón · ESUniversidad de Zaragoza · ESFundacion Agencia Aragonesa para la Investigacion y el Desarrollo · ESImmunité et Cancer · FRUniversité de Montpellier · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have previously shown that the development of a major histocompatibility complex class I (MHC-I)-deficient tumor was favored in protein kinase C-θ knockout (PKC-θ

Indexed as

CDK8, cyclin-dependent kinase 8CXCL10CXCL10, (C-X-C motif) ligand 10/CXCL10FCS, fetal calf serumIFNA1IFN-α, IL-15IFNα, interferon-αIFNγ, interferon-γ, IFNGIL-15, interleukin-15/IL15mAb, monoclonal antibodyMACS, magnetic cell separationMEF, murine embryonic fibroblastMHC-I, major histocompability complex class I/MHC-INK cellsNK, natural killerPI3K, phosphatidylinositol-3-kinasePKC-θPKC-θ, protein kinase C-θ, PRKCQPLC, phospholipase-CPoly I:C, poly-inosinic:cytidilic acidRT-PCR, real-time polymerase chain reactionSTAT-1, signal transducer and activator of transcription-1/STAT1.

Identifiers

PMID25960930
PMCPMC4368137
OpenAlexW2010813474

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.