ReviewOman medical journal2015
Khat use: history and heart failure.
Review in Oman medical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Does regular Khat (Catha edulis) chewing in adults increase the risk of hypertension compared to non-use? A systematic review and meta-analysis.BMC cardiovascular disorders · 2025Pooled it
- Evaluation of a Mass Media Educational Campaign to Increase Secondary School Students' Awareness of Health Risks of Khat Chewing: A Quasi-Experimental Pre-Post Study in Aden, Yemen.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Basal-bolus regimen versus twice-daily premixed insulin in the treatment of childhood type 1 diabetes mellitus in Mosul City: A comparison study.Problemy endokrinologii · 2026Article
- An evolutionary perspective on the use of betel nut and its effects on health outcomes.Evolution, medicine, and public health · 2026Article
- The regulation and control of khat use and access in Ethiopia: Policy brief.Global mental health (Cambridge, England) · 2026Review
- The association of third molars with mandibular incisor crowding in a group of the Yemeni population in Sana'a city: cone-beam computed tomography.BMC oral health · 2025Article
- Understanding the Intricacies of Khat-Associated Cardiovascular Disease.Journal of clinical medicine · 2025Review
- Substance use among young people in the West Arsi Zone, Ethiopia: A cross-sectional study.PloS one · 2025Article
- From traditional to transactional: exploration of khat use in Ethiopia through an interpretative phenomenological analysis.BMC public health · 2024Article
- Effects of congeners of amphetamine on the human heart.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Chewing Khat (International journal of general medicine · 2024Article
- Risk of acute coronary syndrome and relationship with the use of khat and tobacco products in the Jazan region, Saudi Arabia: A prospective case-control study.Tobacco induced diseases · 2024Article
- Khat use and related determinants among pregnant women within Haramaya, Ethiopia: a mixed methods study.Frontiers in global women's health · 2024Article
- Dukak - a pathognomonic symptom of khat withdrawal?Psychopharmacology · 2023Article
- The impact of khat chewing on heart activity and rehabilitation therapy from khat addiction in healthy khat chewers.Scientific reports · 2022Article
- Review
- Awareness of heart disease and associated health behaviours in a developing country: A qualitative study.Nursing open · 2022Article
- Substance use and substance use disorders in Africa: An epidemiological approach to the review of existing literature.World journal of psychiatry · 2022Review
- In vitro metabolic profile of mexedrone, a mephedrone analog, studied by high- and low-resolution mass spectrometry.Drug testing and analysis · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent reports suggest that 20 million people worldwide are regularly using khat as a stimulant, even though the habit of chewing khat is known to cause serious health issues. Historical evidence suggests khat use has existed since the 13th century in Ethiopia and the southwestern Arabian regions even before the cultivation and use of coffee. In the past three decades, its availability and use spread all over the world including the United States and Europe. Most of the consumers in the Western world are immigrant groups from Eastern Africa or the Middle East. The global transport and availability of khat has been enhanced by the development of synthetic forms of its active component. The World Health Organization considers khat a drug of abuse since it causes a range of health problems. However, it remains lawful in some countries. Khat use has long been a part of Yemeni culture and is used in virtually every social occasion. The main component of khat is cathinone, which is structurally and functionally similar to amphetamine and cocaine. Several studies have demonstrated that khat chewing has unfavorable cardiovascular effects. The effect on the myocardium could be explained by its effect on the heart rate, blood pressure, its vasomotor effect on the coronary vessels, and its amphetamine-like effects. However, its direct effect on the myocardium needs further elaboration. To date, there are few articles that contribute death among khat chewers to khat-induced heart failure. Further studies are needed to address the risk factors in khat chewers that may explain khat-induced cardiotoxicity, cardiomyopathy, and heart failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.