Evidence map›Paper›PMID 25960691›Full record

ArticleCancer cell international2015

MicroRNA (miRNA) in cancer.

Kaladhar B Reddy

Open access · goldAbstract read
In one paragraph

Article in Cancer cell international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 321 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
321citing papers in PubMed, 4 pooled it
14.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

321 citing papers in PubMed, 4 syntheses or guidelines pooled it, 606 citations in OpenAlex.

  1. Pooled it
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  3. Pooled it
  4. The Role of microRNAs in Heart Failure: A Systematic Review.Frontiers in cardiovascular medicine · 2020
    Pooled it
  5. Review
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  7. Genes · 2026
    Review
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261 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Kaladhar B ReddyDepartment of Pathology, Wayne State University School of Medicine, 540 E. Canfield Anvenue, Detroit, MI 48201 USA ; Karmanos Cancer Institute, Wayne State University, Detroit, MI USA.
Wayne State University · US

Funding

Racial Disparities in Breast Cancer and the role of micro-RNAsR21CA178152 · NCI · WAYNE STATE UNIVERSITY · PI REDDY, KALADHAR B. · 2013 to 2014
$358k
NCI NIH HHS R21 CA178152
6 · The paper itself

Abstract

In recent years, there has been a tremendous and growing interest among researchers to investigate the role of mircoRNA (miRNA) in normal cellular as well as in disease processes. miRNAs are a family of small non-coding RNAs which were reported to regulate the expression of various oncogenes or tumor suppressor genes. The expression profiling of miRNAs has already entered into cancer clinics as diagnostic and prognostic biomarkers to assess tumor initiation, progression and response to treatment in cancer patients. This review summarizes: (i) the current understanding of interactions between miRNAs and their target genes, (ii) recent advances in the regulatory mechanisms that control the expression of genes related to carcinogenesis, and (iii) the role of miRNAs in cancer diagnosis and therapy.

Indexed as

CancerDiagnosisDNA methylationmiRNASingle nucleotide polymorphismTherapy

Identifiers

PMID25960691
PMCPMC4424445
OpenAlexW2151821775

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.