ArticleNature communications2015
Commissural axonal corridors instruct neuronal migration in the mouse spinal cord.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Co-option and innovation in neural crest evolution.Science advances · 2026Review
- Evidence for chronological diversification of spinal neuron subtypes by a shared sequence of transcription factors.Science advances · 2026Article
- Neurotrophin-3 produced by motor neurons non-cell autonomously regulate the development of pre-motor interneurons in the developing spinal cord.bioRxiv : the preprint server for biology · 2026Article
- Impaired dynein function preserves spinal interneuron survival and positioning in an ALS-like mouse model.PloS one · 2026Article
- Heparan sulfate endosulfatases, Sulf1 and Sulf2, are required for formation of the medial habenula-interpeduncular nucleus circuit.Frontiers in neuroanatomy · 2026Article
- A global gene regulatory program and its region-specific regulator partition neurons into commissural and ipsilateral projection types.Science advances · 2024Article
- Embryonic temporal-spatial delineation of excitatory spinal V3 interneuron diversity.Cell reports · 2024Article
- Endothelial PlexinD1 signaling instructs spinal cord vascularization and motor neuron development.Neuron · 2022Article
- Alternative LIM homeodomain splice variants are dynamically regulated at key developmental steps in vertebrates.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- Robo2 Receptor Gates the Anatomical Divergence of Neurons Derived From a Common Precursor Origin.Frontiers in cell and developmental biology · 2021Article
- Dorsal commissural axon guidance in the developing spinal cord.Current topics in developmental biology · 2021Review
- The Temporal Neurogenesis Patterning of Spinal p3-V3 Interneurons into Divergent Subpopulation Assemblies.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Roles of axon guidance molecules in neuronal wiring in the developing spinal cord.Nature reviews. Neuroscience · 2019Review
- Netrin1 establishes multiple boundaries for axon growth in the developing spinal cord.Developmental biology · 2017Article
- Netrin1 Produced by Neural Progenitors, Not Floor Plate Cells, Is Required for Axon Guidance in the Spinal Cord.Neuron · 2017Article
- Evolution of the functionally conserved DCC gene in birds.Scientific reports · 2017Article
- Pattern activation/recognition theory of mind.Frontiers in computational neuroscience · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unravelling how neurons are guided during vertebrate embryonic development has wide implications for understanding the assembly of the nervous system. During embryogenesis, migration of neuronal cell bodies and axons occurs simultaneously, but to what degree they influence each other's development remains obscure. We show here that within the mouse embryonic spinal cord, commissural axons bisect, delimit or preconfigure ventral interneuron cell body position. Furthermore, genetic disruption of commissural axons results in abnormal ventral interneuron cell body positioning. These data suggest that commissural axonal fascicles instruct cell body position by acting either as border landmarks (axon-restricted migration), which to our knowledge has not been previously addressed, or acting as cellular guides. This study in the developing spinal cord highlights an important function for the interaction of cell bodies and axons, and provides a conceptual proof of principle that is likely to have overarching implications for the development of neuronal architecture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.