Evidence map›Paper›PMID 25960347›Full record

ReviewBrain research2015

High-resolution in vivo optical imaging of stroke injury and repair.

Sava Sakadžić, Jonghwan Lee, David A Boas, Cenk Ayata

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Brain research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Mapping OScientific reports · 2020
    Article
  9. Review
  10. Article
  11. Article
  12. Optical imaging and modulation of neurovascular responses.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018
    Review
  13. Review
  14. Imaging of oxygen and hypoxia in cell and tissue samples.Cellular and molecular life sciences : CMLS · 2018
    Review
  15. Article
  16. Brain Vascular Imaging Techniques.International journal of molecular sciences · 2016
    Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sava SakadžićOptics Division, MHG/MIT/HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA. Electronic address: sava.sakadzic@mgh.harvard.edu.
Jonghwan LeeOptics Division, MHG/MIT/HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
David A BoasOptics Division, MHG/MIT/HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Cenk AyataNeurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA; Stroke Service and Neuroscience Intensive Care Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

Funding

Spatiotemporal Brain Imaging: Microscopic &System LevelR01EB000790 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DALE, ANDERS M · 2002 to 2015
$15.3M
Targeting ROCK for Neurogliovascular Plasticity & Remodeling After StrokeP01NS055104 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LO, ENG H. · 2007 to 2018
$13.3M
Two-Photon Microscopy of Oxygen Consumption in the BrainR01NS091230 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SAKADZIC, SAVA · 2015 to 2019
$2.4M
Neural & Vascular Dysfunction As Mechanisms of Injury in Genetic Migraine ModelsR01NS061505 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI AYATA, CENK · 2008 to 2012
$1.8M
Dendritic upconverting nanoparticles for multiphoton imaging and sensingR01EB018464 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI VINOGRADOV, SERGEI · 2014 to 2017
$1.5M
In Vivo Imaging Alzheimers Disease Pathology with 2-Photon/Lifetime MicroscopyK99AG042026 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI YASEEN, MOHAMMAD ABBAS · 2013 to 2014
$274k
Microscopic imaging of neuro-capillary coupling in brain cortexK99EB014879 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, JONGHWAN · 2013 to 2014
$180k
NIA NIH HHS K99 AG042026NIBIB NIH HHS EB000790NIBIB NIH HHS EB018464NIBIB NIH HHS K99 EB014879NIBIB NIH HHS K99EB014879NIBIB NIH HHS R01 EB000790NIBIB NIH HHS R01 EB018464NINDS NIH HHS NS055104NINDS NIH HHS NS061505NINDS NIH HHS P01 NS055104NINDS NIH HHS R01 NS061505NINDS NIH HHS R01 NS091230
6 · The paper itself

Abstract

Central nervous system (CNS) function and dysfunction are best understood within a framework of interactions between neuronal, glial and vascular compartments comprising the neurovascular unit (NVU), all of which contribute to stroke-induced CNS injury, plasticity, repair, and recovery. Recent advances in in vivo optical microscopy have enabled us to observe and interrogate cells and their processes with high spatial resolution in real time and in their natural environment deep in the brain tissue. Here, we review some of these state-of-the-art imaging techniques with an emphasis on imaging the interactions among the constituents of the NVU during ischemic injury and repair in small animal models. This article is part of a Special Issue entitled SI: Cell Interactions In Stroke.

Indexed as

AnimalsBrainCell CommunicationOptical ImagingStrokeCellular imagingHigh-resolutionMulti-photon microscopyOptical coherence tomographyOptical imagingPhotoacoustic imagingStroke

Identifiers

PMID25960347
PMCPMC4569527

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.