Evidence map›Paper›PMID 25960175›Full record

ArticleJournal of immunological methods2015

Identification of T cell clones without the need for sequencing.

Ryan J Martinez, Dennis K Neeld, Brian D Evavold

Abstract read
In one paragraph

Article in Journal of immunological methods, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Development of anFuture science OA · 2019
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ryan J MartinezDepartment of Microbiology and Immunology, 1510 Clifton Rd NE, Emory University, Atlanta, GA 30322, USA.
Dennis K NeeldDepartment of Microbiology and Immunology, 1510 Clifton Rd NE, Emory University, Atlanta, GA 30322, USA.
Brian D EvavoldDepartment of Microbiology and Immunology, 1510 Clifton Rd NE, Emory University, Atlanta, GA 30322, USA. Electronic address: bevavol@emory.edu.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008169 · NIGMS · EMORY UNIVERSITY · PI GROSS, ROBERT E · 1987 to 2021
$20.3M
TRAINING IN IMMUNOLOGY AND MOLECULAR PATHOGENESIST32AI007610 · NIAID · EMORY UNIVERSITY · PI EVAVOLD, BRIAN D · 2000 to 2014
$4.4M
CD4+ T cell affinity for self and foreign antigens in the CNSR01NS071518 · NINDS · UNIVERSITY OF UTAH · PI EVAVOLD, BRIAN D · 2010 to 2021
$3.3M
Advanced Research Training in Transplantation ScienceT32AI070081 · NIAID · EMORY UNIVERSITY · PI Mandy L Ford · 2006 to 2026
$3.1M
Peptide:MHC stability and potency of T cell responsesR01AI056017 · NIAID · EMORY UNIVERSITY · PI EVAVOLD, BRIAN D. · 2005 to 2007
$1.1M
Myelin specific T and B cell differentiation during EAEF31NS086130 · NINDS · EMORY UNIVERSITY · PI MARTINEZ, RYAN J · 2014 to 2014
$48k
NIAID NIH HHS R01 AI056017NIAID NIH HHS T32 AI007610NIAID NIH HHS T32 AI070081NIGMS NIH HHS T32 GM008169NINDS NIH HHS F31 NS086130NINDS NIH HHS R01 NS071518NINDS NIH HHS R01NS071518
6 · The paper itself

Abstract

The brainbow recombination fluorescent protein system has been used for a multitude of applications in fate and lineage tracking. Here, we use a mouse with a ubiquitously expressed brainbow construct, termed the Confetti mouse, to perform T lymphocyte cell lineage tracking. We demonstrate that antigen-specific T lymphocyte clonotypes can be identified and phenotyped using flow cytometry instead of performing expensive and time-consuming methods of single cell sequencing.

Indexed as

AnimalsClone CellsFlow CytometryGene ExpressionGenes, ReporterMiceMice, TransgenicReceptors, Antigen, T-CellSequence Analysis, DNASingle-Cell AnalysisTamoxifenT-LymphocytesT-Lymphocyte SubsetsReceptors, Antigen, T-CellTamoxifenClonotypeLineage trackingT cell receptor

Identifiers

PMID25960175
PMCPMC4560598

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.