Evidence map›Paper›PMID 25960127›Full record

ReviewChemical Society reviews2015

Engineered biosynthesis of natural products in heterologous hosts.

Yunzi Luo, Bing-Zhi Li, Duo Liu, Lu Zhang, Yan Chen, Bin Jia, Bo-Xuan Zeng, Huimin Zhao, Ying-Jin Yuan

Abstract readReview
In one paragraph

Review in Chemical Society reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed.

  1. Engineering non-P450 3-hydroxylase forSynthetic and systems biotechnology · 2025
    Article
  2. Review
  3. Efficient biosynthesis ofSynthetic and systems biotechnology · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Rational construction of genome-minimizedSynthetic and systems biotechnology · 2024
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. EngineeringMetabolic engineering communications · 2023
    Article
  14. The Functional Characteristics and Soluble Expression of SaffronInternational journal of molecular sciences · 2023
    Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yunzi LuoKey Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, P. R. China. yjyuan@tju.edu.cn.
Bing-Zhi Li
Duo Liu
Lu Zhang
Yan Chen
Bin Jia
Bo-Xuan Zeng
Huimin Zhao
Ying-Jin Yuan

Funding

Structural Elucidation and Biosynthesis P01GM077596 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI METCALF, WILLIAM W · 2007 to 2016
$15.3M
NIGMS NIH HHS GM077596NIGMS NIH HHS P01 GM077596
6 · The paper itself

Abstract

Natural products produced by microorganisms and plants are a major resource of antibacterial and anticancer drugs as well as industrially useful compounds. However, the native producers often suffer from low productivity and titers. Here we summarize the recent applications of heterologous biosynthesis for the production of several important classes of natural products such as terpenoids, flavonoids, alkaloids, and polyketides. In addition, we will discuss the new tools and strategies at multi-scale levels including gene, pathway, genome and community levels for highly efficient heterologous biosynthesis of natural products.

Indexed as

BacteriaMetabolic EngineeringAlkaloidsBiological ProductsBiotechnologyFlavonoidsTerpenesAlkaloidsBiological ProductsFlavonoidsTerpenes

Identifiers

PMID25960127
PMCPMC4510016

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.