Trial reportThe Journal of veterinary medical science2015
A comparison of the immunological effects of propofol and isoflurane for maintenance of anesthesia in healthy dogs.
Trial report in The Journal of veterinary medical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Th1/Th2 cytokine polarization in three different anaesthesia protocols administered to cats undergoing ovariohysterectomy.BMC veterinary research · 2026Article
- Effect of Anesthesia on Hematologic Parameters of Female Domestic Swine (Sus scrofa domestica).Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- High carbohydrate is preferable to high lipid parenteral nutrition in healthy dogs undergoing prolonged sedation.Veterinary research communications · 2024Article
- The impact of the transversus abdominis plane block (TAP) on stress response measured through the complete blood- derived inflammatory markers.Veterinary research communications · 2024Article
- Anaesthesia in Veterinary Oncology: The Effects of Surgery, Volatile and Intravenous Anaesthetics on the Immune System and Tumour Spread.Animals : an open access journal from MDPI · 2023Review
- Determination of Embryotoxic Effects of In Ovo Administered Propofol on Peripheral Blood Alpha Naphthyl Acetate Esterase and Acid Phosphatase-Positive Lymphocytes.Turkish journal of anaesthesiology and reanimation · 2023Article
- Tissue Harvesting Site Effect on the Canine Adipose Stromal Vascular Fraction Quantity and Quality.Animals : an open access journal from MDPI · 2021Article
- Article
- Sleeping Beauty: Anesthesia May Promote Relapse in Dogs With Diffuse Large B-Cell Lymphoma in Complete Remission After Chemo-Immunotherapy.Frontiers in veterinary science · 2021Article
- Hematologic Values of Jamaican Fruit Bats (Journal of the American Association for Laboratory Animal Science : JAALAS · 2020Article
- Pharmacokinetics and Immunological Effects of Romidepsin in Rhesus Macaques.Frontiers in immunology · 2020Article
- Impact of general anaesthesia on endoplasmic reticulum stress: propofolInternational journal of medical sciences · 2019Article
- Immune Modulation by Volatile Anesthetics.Anesthesiology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most anesthetics have an immuno-suppressive effect on cellular and neurohumoral immunity, and research shows that total intravenous anesthesia (TIVA) with propofol has a greater immuno-protective effect than inhalational anesthesia in human medicine. However, in veterinary clinics, these effects remain ambiguous. To clarify the details, we focused on propofol and isoflurane, investigating clinical blood hematology and immunological profiles drawn from healthy dogs under and after two anesthesia techniques. Twelve healthy adult beagles were included in this study, randomly assigned to the propofol anesthesia group (group P: n=6) or the isoflurane anesthesia group (group I: n=6). In both groups, the number of lymphocytes in peripheral blood decreased after 2 hr of anesthesia (2 hr), but group P showed significantly less decrease than group I. For T-lymphocyte subsets examined by flowcytometry, the ratio of CD3+, CD4+ and CD8+ lymphocytes in the peripheral blood mononuclear cell (PBMC) of group P at 2 hr also exhibited a high level compared to group I. Moreover, for mRNA expression of cytokines measured by real-time PCR, the IL2 (pro-inflammatory cytokine) of group P showed no decrease like group I. The IL10 (anti-inflammatory cytokine) of group P also showed no increase like group I, while both cytokines maintained nearly the same level until 2 hr. These results suggest that, compared to propofol, isoflurane had more strongly immuno-suppression caused by anesthesia, and propofol itself might have some immuno-protective effects. Thus, TIVA with propofol might benefit immunological support in the perioperative period of dogs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.