ArticleMagnetic resonance in medicine2016
Longitudinal assessment of spinal cord injuries in nonhuman primates with quantitative magnetization transfer.
Article in Magnetic resonance in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Early Detection of Neuroinflammation and White Matter Damage Following Dorsal Spinal Nerve Root Sectioning in a Nonhuman Primate Model.Magnetic resonance in medicine · 2026Article
- Validation of qMT and CEST MRI as Biomarkers of Response to Treatment After Lumbar Spinal Cord Injury in Rats.NMR in biomedicine · 2025Article
- AI-assisted 3D analysis of grasping and reaching behavior of squirrel monkeys during recovery from cervical spinal cord injury.Behavioural brain research · 2025Article
- Longitudinal Imaging of Injured Spinal Cord Myelin and White Matter with 3D Ultrashort Echo Time Magnetization Transfer (UTE-MT) and Diffusion MRI.Journal of imaging · 2024Article
- Model-based parcellation of diffusion MRI of injured spinal cord predicts hand use impairment and recovery in squirrel monkeys.Behavioural brain research · 2024Article
- Longitudinal multiparametric MRI of traumatic spinal cord injury in animal models.Magnetic resonance imaging · 2023Review
- Machine-learning-based video analysis of grasping behavior during recovery from cervical spinal cord injury.Behavioural brain research · 2023Article
- Macromolecular Proton Fraction as a Myelin Biomarker: Principles, Validation, and Applications.Frontiers in neuroscience · 2022Review
- How to generate graded spinal cord injuries in swine - tools and procedures.Disease models & mechanisms · 2021Article
- Improving Diagnostic Workup Following Traumatic Spinal Cord Injury: Advances in Biomarkers.Current neurology and neuroscience reports · 2021Review
- Longitudinal changes in DTI parameters of specific spinal white matter tracts correlate with behavior following spinal cord injury in monkeys.Scientific reports · 2020Article
- Quantitative Magnetization Transfer Detects Renal Fibrosis in Murine Kidneys With Renal Artery Stenosis.Journal of magnetic resonance imaging : JMRI · 2020Article
- Optimization of a transmit/receive surface coil for squirrel monkey spinal cord imaging.Magnetic resonance imaging · 2020Article
- Longitudinal assessment of recovery after spinal cord injury with behavioral measures and diffusion, quantitative magnetization transfer and functional magnetic resonance imaging.NMR in biomedicine · 2020Article
- Noninvasive quantitative magnetization transfer MRI reveals tubulointerstitial fibrosis in murine kidney.NMR in biomedicine · 2019Article
- Spatiotemporal trajectories of quantitative magnetization transfer measurements in injured spinal cord using simplified acquisitions.NeuroImage. Clinical · 2019Article
- Assessment of renal fibrosis in murine diabetic nephropathy using quantitative magnetization transfer MRI.Magnetic resonance in medicine · 2018Article
- Assessment of unilateral ureter obstruction with multi-parametric MRI.Magnetic resonance in medicine · 2018Article
- MRI evaluation of regional and longitudinal changes in Z-spectra of injured spinal cord of monkeys.Magnetic resonance in medicine · 2018Article
- Differential fMRI Activation Patterns to Noxious Heat and Tactile Stimuli in the Primate Spinal Cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposeThis study aimed to evaluate the reproducibility and specificity of quantitative magnetization transfer (qMT) imaging for monitoring spinal cord injuries (SCIs).
methodsMRI scans were performed in anesthetized monkeys at 9.4T, before and serially after a unilateral lesion of the cervical spinal cord. A two-pool fitting model was used to derive qMT parameters.
resultsqMT measures were reproducible across normal subjects, with an average pool size ratio (PSR) of 0.086 ± 0.003 (mean ± SD) for gray matter, and 0.120 ± 0.005 for white matter, respectively. Compared with normal gray matter, the PSR of abnormal tissues rostral and caudal to the injury site decreased by 19.5% (P < 0.05), while the PSR of the cyst-like volume decreased drastically weeks after SCI. Strong correlations in cyst-like regions were observed between PSR and other MRI measures including longitudinal relaxation rate (R1 ), apparent diffusion coefficient and fractional anisotropy (FA). Decreased PSR and FA values correlated well with demyelination in abnormal tissues.
conclusionThe qMT parameters provide robust and specific information about the molecular and cellular changes produced by SCI. PSR detected demyelination and loss of macromolecules in abnormal tissue regions rostral and caudal to the cyst/lesion sites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.